| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway, as determined by network pharmacology
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhuo-Cong Bao, Ye Zhang, Zhao-Dong Liu, Hui-Jun Dai, Fu Ren, Ning Li, Shang-Yu Lv and Yan Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Central Government Guides Local Science and Technology Development Fund |
2023JH6/100100021 |
| Liaoning Province Education Department Foundation of China |
JYTMS20231393 |
| Scientific Research Project of the Liaoning Province Education Department |
SYYX2019015 |
| Science and Technology Foundation of Shenyang Medical College |
20171004 |
| the Science and Technology Innovation Fund for Master Students of Shenyang Medical College |
Y20220509 |
| Liaoning Province Education Department Foundation of China |
LJ212410164032 |
|
| Corresponding Author |
Yan Zhang, Associate Professor, PhD, International Education School, International Exchange and Cooperation Office, Shenyang Medical College, No. 146 North Huanghe Street, Shenyang 110034, Liaoning Province, China. zhangyan@symc.edu.cn |
| Key Words |
Hepatocellular carcinoma cells; Tetrahydrocurcumin; TP53; Network pharmacology; Molecular docking |
| Core Tip |
This study investigated the molecular mechanisms by which tetrahydrocurcumin (THC), a derivative of curcumin, inhibits hepatocellular carcinoma cells. Utilizing a comprehensive approach that integrated network pharmacology, molecular docking, and in vitro experiments, the TP53 signaling pathway was identified as a critical mediator of the antitumor activity of THC. |
| Publish Date |
2025-02-14 10:33 |
| Citation |
<p>Bao ZC, Zhang Y, Liu ZD, Dai HJ, Ren F, Li N, Lv SY, Zhang Y. Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway, as determined by network pharmacology. <i>World J Gastrointest Oncol</i> 2025; 17(3): 101174</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i3/101174.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i3.101174 |
