Publication Name	World Journal of Psychiatry
Manuscript ID	101178
Country	China

Received	2024-09-25 07:07
Peer-Review Started	2024-09-25 07:07
To Make the First Decision
Return for Revision	2024-10-23 10:41
Revised	2024-11-26 13:20
Second Decision	2024-12-27 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-27 07:47
Articles in Press	2024-12-27 07:47
Publication Fee Transferred	2024-11-28 09:19
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-24 09:24
Publish the Manuscript Online	2025-02-26 04:37

ISSN	2220-3206 (online)
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Category	Psychiatry
Manuscript Type	Basic Study
Article Title	Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Yu Li, Shu-Jun Zhang, Jia-Lu Xu, Yan Yang, Zhi-Xuan Zeng and De-Lin Ma
ORCID	Author(s) ORCID Number Zhi-Xuan Zeng http://orcid.org/0000-0001-9740-1342 De-Lin Ma http://orcid.org/0000-0001-5039-7251
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82300894
Corresponding Author	De-Lin Ma, Associate Chief Physician, PhD, Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. maderine4@163.com
Key Words	Diabetes; Cognitive dysfunction; Voltage-gated proton channel 1; Neuroinflammation; Myelin regeneration
Core Tip	This study demonstrates that voltage-gated proton channel 1 (HV-1) knockout reduces neuroinflammation and alleviates axonal demyelination in diabetic mice, suggesting that HV-1 is a potential therapeutic target for treating diabetes-associated cognitive decline. The findings highlight the role of HV-1 in modulating microglial activity and promoting oligodendrocyte survival, which contributes to improved cognitive function in diabetic models. These insights offer new avenues for developing strategies to mitigate cognitive dysfunction related to diabetes by targeting HV-1.
Publish Date	2025-02-26 04:37
Citation	<p>Li CY, Zhang SJ, Xu JL, Yang Y, Zeng ZX, Ma DL. Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination. <i>World J Psychiatry</i> 2025; 15(3): 101178</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i3/101178.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i3.101178

Full Article (PDF)	WJP-15-101178-with-cover.pdf
The ARRIVE Guidelines	101178-The-ARRIVE-Guidelines.pdf
Manuscript File	101178_Auto_Edited_062252.docx
Answering Reviewers	101178-answering-reviewers.pdf
Audio Core Tip	101178-audio.mp3
Biostatistics Review Certificate	101178-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	101178-conflict-of-interest-statement.pdf
Copyright License Agreement	101178-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101178-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	101178-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	101178-non-native-speakers.pdf
Peer-review Report	101178-peer-reviews.pdf
Scientific Misconduct Check	101178-scientific-misconduct-check.png
Scientific Editor Work List	101178-scientific-editor-work-list.pdf
CrossCheck Report	101178-crosscheck-report.png
CrossCheck Report	101178-crosscheck-report.pdf