| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Case Control Study |
| Article Title |
Metabolic pathway modulation by olanzapine: Multitarget approach for treating violent aggression in patients with schizophrenia
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Ning Song, Shuang Xia, Zhi Sun, Yong-Chao Chen, Lu Jiao, Wen-Hua Wan, Hong-Wei Zhang, Xiao Guo, Hua Guo, Shou-Feng Jia, Xiao-Xin Li, Shi-Xian Cao, Li-Bin Fu, Meng-Meng Liu, Tian Zhou, Lv-Feng Zhang and Qing-Quan Jia |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Henan Provincial Science and Technology Research Project |
242102310203 |
|
| Corresponding Author |
Zhi Sun, PhD, Professor, Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. sunzhi2013@163.com |
| Key Words |
Schizophrenia; Violent aggression; Olanzapine; Metabolomics; Network pharmacology |
| Core Tip |
Violent aggression is an important symptom of schizophrenia that causes serious harm to society and public health. This study integrated network pharmacology with blood metabolomics to explore the pathogenesis of violent aggression in patients with schizophrenia and the metabolic regulatory mechanism of olanzapine, establishing theoretical basis for fundamental research and clinical application of olanzapine in the treatment of violent aggression in patients with schizophrenia. |
| Publish Date |
2024-12-18 08:36 |
| Citation |
<p>Song YN, Xia S, Sun Z, Chen YC, Jiao L, Wan WH, Zhang HW, Guo X, Guo H, Jia SF, Li XX, Cao SX, Fu LB, Liu MM, Zhou T, Zhang LF, Jia QQ. Metabolic pathway modulation by olanzapine: Multitarget approach for treating violent aggression in patients with schizophrenia. <i>World J Psychiatry</i> 2025; 15(1): 101186</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i1/101186.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i1.101186 |
