| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Loss-of-Function Mutations of MicroRNA-142-3p Promote ASH1L Expression to induce Immune Evasion and Hepatocellular Carcinoma Progression
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xing-Hui Yu, Yan Xie, Jian Yu, Kun-Ning Zhang, Zhou-Bo Guo, Di Wang, Zhao-Xian Li, Wei-Qi Zhang, Yu-Ying Tan, Li Zhang and Wen-Tao Jiang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Haihe Laboratory of Cell Ecosystem Innovation Fund |
No. 22HHXBJC00001 |
| Key Discipline Special Project of Tianjin Municipal Health Commission |
No. TJWJ2022XK016 |
|
| Corresponding Author |
Wen-Tao Jiang, MD, PhD, School of Medicine, Nankai University, No. 94 Weijin Road, Nankai District, Tianjin 300192, China. jiangwentao@nankai.edu.cn |
| Key Words |
Hepatocellular carcinoma; MicroRNA-142-3p; ASH1L; Immune evasion; Tumor immune microenvironment; Apoptosis |
| Core Tip |
This article mainly focuses on the new targets which may be beneficial to treat and predict HCC. We would like to shed light on the effects of MIR-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC patients. Based on the experiments, loss function of microRNA-142-3p induces cancer progression and immune evasion through upregulation of ASH1L in hepatocellular carcinoma. Both microRNA-142-3p and ASH1L can feature as new biomarker for hepatocellular carcinoma in the future. In-depth comprehensive research is indispensable to completely clarity the ASH1L pathology and relevant molecular mechanisms in HCC progression. |
| Publish Date |
2024-12-09 10:40 |
| Citation |
Yu XH, Xie Y, Yu J, Zhang KN, Guo ZB, Wang D, Li ZX, Zhang WQ, Tan YY, Zhang L, Jiang WT. Loss-of-Function Mutations of MicroRNA-142-3p Promote ASH1L Expression to induce Immune Evasion and Hepatocellular Carcinoma Progression. World J Gastroenterol 2025; 31(1): 101198 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i1/101198.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i1.101198 |
