Publication Name	World Journal of Experimental Medicine
Manuscript ID	101289
Country	South Korea

Received	2024-09-11 04:01
Peer-Review Started	2024-09-19 01:13
To Make the First Decision
Return for Revision	2024-10-25 03:51
Revised	2024-11-05 14:19
Second Decision	2024-11-20 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-20 09:25
Articles in Press	2024-11-20 09:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-20 00:18
Publish the Manuscript Online	2024-12-26 03:04

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Editorial on amylase and the acini–islet–acinar reflex: A new frontier in metabolic health research
Manuscript Source	Invited Manuscript
All Author List	Opeyemi Deji-Oloruntoba, Uchenna E Okpete and Haewon Byeon
ORCID	Author(s) ORCID Number Opeyemi Deji-Oloruntoba http://orcid.org/0009-0004-4332-0837 Uchenna E Okpete http://orcid.org/0000-0003-3803-4583 Haewon Byeon http://orcid.org/0000-0002-3363-390X
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education No. NRF-RS-2023-00237287 Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education No. NRF-2021S1A5A8062526 Local Government-University Cooperation-Based Regional Innovation Projects No. 2021RIS-003
Corresponding Author	Haewon Byeon, Associate Professor, PhD, Department of Digital Anti-aging Healthcare (BK21), Inje University, 197 Injero, Gimhae 50834, South Korea. bhwpuma@naver.com
Key Words	Alpha-Amylase; Insulin secretion; Glucose metabolism; Pancreatic signaling; Metabolic regulation; Acino-insular axis
Core Tip	This editorial emphasizes the critical role of α-amylase, an enzyme essential for starch digestion, in metabolic regulation beyond its digestive function. Recent studies, including that of Pierzynowska et al, demonstrate that amylase can inhibit insulin secretion, delaying glucose clearance and increasing blood sugar levels, with effects persisting even after the infusion. This suggests amylase’s influence on pancreatic signaling and confirms the existence of the acini-islet-acinar reflex. Understanding the broader metabolic role of amylase may open therapeutic avenues for conditions like diabetes and obesity through enzyme supplementation, highlighting the need for further research into its regulatory mechanisms.
Publish Date	2024-12-26 03:04
Citation	<p>Deji-Oloruntoba O, Okpete UE, Byeon H. Editorial on amylase and the acini–islet–acinar reflex: A new frontier in metabolic health research. <i>World J Exp Med</i> 2025; 15(1): 101289</p>
URL	https://www.wjgnet.com/2220-315x/full/v15/i1/101289.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i1.101289

Full Article (PDF)	WJEM-15-101289-with-cover.pdf
Manuscript File	101289_Auto_Edited_014048.docx
Answering Reviewers	101289-answering-reviewers.pdf
Audio Core Tip	101289-audio.mp3
Conflict-of-Interest Disclosure Form	101289-conflict-of-interest-statement.pdf
Copyright License Agreement	101289-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101289-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	101289-non-native-speakers.pdf
Peer-review Report	101289-peer-reviews.pdf
Scientific Misconduct Check	101289-scientific-misconduct-check.png
Scientific Editor Work List	101289-scientific-editor-work-list.pdf
CrossCheck Report	101289-crosscheck-report.png
CrossCheck Report	101289-crosscheck-report.pdf