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Articles Published Processes
4/23/2025 3:33:30 AM | Browse: 131 | Download: 752
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Received |
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2024-09-10 03:29 |
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Peer-Review Started |
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2024-09-10 03:29 |
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First Decision by Editorial Office Director |
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2024-10-28 08:16 |
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Return for Revision |
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2024-10-28 08:16 |
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Revised |
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2024-12-13 09:22 |
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Publication Fee Transferred |
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2024-12-23 03:47 |
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Second Decision by Editor |
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2025-02-18 02:43 |
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Second Decision by Editor-in-Chief |
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2025-02-19 01:15 |
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Final Decision by Editorial Office Director |
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2025-03-21 11:01 |
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Articles in Press |
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2025-03-21 11:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-10 03:33 |
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Publish the Manuscript Online |
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2025-04-23 03:33 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
RNA interference-mediated osteoprotegerin silencing increases the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio and promotes osteoclastogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Song-Guan Wei, Hui-Hong Chen, Liu-Rong Xie, Yuan Qin, Yu-Ying Mai, Lin-Hui Huang and Hong-Bing Liao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82160192 |
| Guangxi Science and Technology Program |
2023AB23037 |
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| Corresponding Author |
Hong-Bing Liao, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, College & Hospital of Stomatology, Guangxi Medical University, No. 22 Shuangyong Road, Qingxiu District, Nanning 530021, Guangxi Zhuang Autonomous Region, China. hongbing_liao@gxmu.edu.cn |
| Key Words |
Osteoprotegerin; Receptor activator of nuclear factor-kappa B ligand; Bone marrow-derived mesenchymal stem cells; RNA interference; Osteoclast; Bone scaffold |
| Core Tip |
This study reports, for the first time, that enhancing the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin (RANKL/OPG) ratio through RNA interference promotes osteoclastogenesis. Our findings reveal a significant upregulation of RANKL mRNA levels after OPG gene silencing. The study demonstrates a significant downregulation of OPG mRNA and protein levels. The increase in the RANKL/OPG ratio significantly promotes osteoclastogenesis. This study provides a new theoretical basis and molecular targets for degrading bone scaffolds and bone tissue repair. |
| Publish Date |
2025-04-23 03:33 |
| Citation |
Wei SG, Chen HH, Xie LR, Qin Y, Mai YY, Huang LH, Liao HB. RNA interference-mediated osteoprotegerin silencing increases the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio and promotes osteoclastogenesis. World J Stem Cells 2025; 17(4): 101290 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i4/101290.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i4.101290 |
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