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Articles Published Processes
11/17/2014 3:13:00 PM | Browse: 1137 | Download: 1511
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Received |
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2014-03-15 13:50 |
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Peer-Review Started |
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2014-03-15 23:07 |
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To Make the First Decision |
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2014-05-13 20:23 |
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Return for Revision |
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2014-05-21 08:53 |
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Revised |
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2014-06-13 00:00 |
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Second Decision |
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2014-07-11 17:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-07-11 17:21 |
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Articles in Press |
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2014-07-11 17:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-07-20 15:52 |
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Typeset the Manuscript |
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2014-11-01 13:37 |
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Publish the Manuscript Online |
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2014-11-17 15:12 |
Category |
Biotechnology & Applied Microbiology |
Manuscript Type |
Autobiography |
Article Title |
GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Xiao-Min Xin, Mu-Xiao Zhong, Gong-Li Yang, Yao Peng, Ya-Li Zhang and Wei Zhu |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Guangdong Provincial Science and Technology Projects |
2011B050400009 |
Scientific Research Projects of Hubei Province Education Department |
B2014055 |
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Corresponding Author |
Wei Zhu, PhD, Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Avenue, Baiyun District, Guangzhou 510515, Guangdong Province, China. chnz_w@126.com |
Key Words |
Farnesoid X receptor; Adipokines; Adipokine receptors; 3T3-L1 cells; HepG2 cells; Nonalcoholic fatty liver disease |
Core Tip |
Our study emphasizes for the first time the effect of GW4064, a synthetic farnesoid X receptor (FXR) agonist, on the expression of adipokines and their receptors, and indicates that the way FXR agonist may act in the progress of nonalcoholic fatty liver disease (NAFLD) is at least partially through regulating the expression of adipokines and their receptors. Therefore, our data provide a further theoretical basis for using an FXR agonist in the therapeutic approach of NAFLD. |
Publish Date |
2014-11-17 15:12 |
Citation |
Xin XM, Zhong MX, Yang GL, Peng Y, Zhang YL, Zhu W. GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells. World J Gastroenterol 2014; 20(42): 15727-15735 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i42/15727.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i42.15727 |
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