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1/21/2025 9:26:55 AM | Browse: 136 | Download: 857
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Received |
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2024-09-11 19:30 |
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Peer-Review Started |
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2024-09-12 01:00 |
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First Decision by Editorial Office Director |
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2024-10-25 13:36 |
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Return for Revision |
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2024-10-25 13:36 |
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Revised |
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2024-12-06 08:37 |
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Publication Fee Transferred |
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2024-12-11 14:37 |
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Second Decision by Editor |
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2024-12-30 04:19 |
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Second Decision by Editor-in-Chief |
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2024-12-31 09:42 |
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Final Decision by Editorial Office Director |
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2025-01-02 03:31 |
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Articles in Press |
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2025-01-02 03:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-01-13 03:42 |
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Publish the Manuscript Online |
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2025-01-21 09:26 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
SMAD specific E3 ubiquitin protein ligase 1 accelerates diabetic macular edema progression by WNT inhibitory factor 1
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Fang Liang, Jia-Qi Zhao, Yi-Fei Wu, Hui-Jie Chen, Tian Huang and Xiao-He Lu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Guangdong Province of China |
2022A1515012346 |
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| Corresponding Author |
Xiao-He Lu, Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, No. 253 Gongye Avenue Central, Guangzhou 515282, Guangdong Province, China. luxh63@163.com |
| Key Words |
Diabetic macular edema; Retinal pigment epithelium cells; Autophagy; SMAD specific E3 ubiquitin protein ligase 1; WNT inhibitory factor 1; N6-methyladenosine modification; Vascular endothelial growth factor signaling pathway |
| Core Tip |
In this study, we demonstrated that insulin like growth factor 2 mRNA binding protein 2 upregulates SMAD-specific E3 ubiquitin protein ligase (SMURF) 1 expression in an N6-methyladenosine-dependent manner, and subsequently SMURF1 activates the Wnt/β-catenin-vascular endothelial growth factor signaling pathway by promoting ubiquitination and degradation of WNT inhibitory factor 1 to promote autophagy, which ultimately disrupts the tight junctions of the retinal pigment epithelium cells and thus led to diabetic macular edema. |
| Publish Date |
2025-01-21 09:26 |
| Citation |
Liang LF, Zhao JQ, Wu YF, Chen HJ, Huang T, Lu XH. SMAD specific E3 ubiquitin protein ligase 1 accelerates diabetic macular edema progression by WNT inhibitory factor 1. World J Diabetes 2025; 16(3): 101328 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i3/101328.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i3.101328 |
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