Publication Name	World Journal of Diabetes
Manuscript ID	101328
Country	China

Received	2024-09-11 19:30
Peer-Review Started	2024-09-12 01:00
To Make the First Decision
Return for Revision	2024-10-25 13:36
Revised	2024-12-06 08:37
Second Decision	2024-12-30 04:19
Accepted by Journal Editor-in-Chief	2024-12-31 09:42
Accepted by Executive Editor-in-Chief	2025-01-02 03:31
Articles in Press	2025-01-02 03:31
Publication Fee Transferred	2024-12-11 14:37
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-13 03:42
Publish the Manuscript Online	2025-01-21 09:26

ISSN	1948-9358 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	SMAD specific E3 ubiquitin protein ligase 1 accelerates diabetic macular edema progression by WNT inhibitory factor 1
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Fang Liang, Jia-Qi Zhao, Yi-Fei Wu, Hui-Jie Chen, Tian Huang and Xiao-He Lu
ORCID	Author(s) ORCID Number Xiao-He Lu http://orcid.org/0000-0003-2173-7290
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Guangdong Province of China 2022A1515012346
Corresponding Author	Xiao-He Lu, Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, No. 253 Gongye Avenue Central, Guangzhou 515282, Guangdong Province, China. luxh63@163.com
Key Words	Diabetic macular edema; Retinal pigment epithelium cells; Autophagy; SMAD specific E3 ubiquitin protein ligase 1; WNT inhibitory factor 1; N6-methyladenosine modification; Vascular endothelial growth factor signaling pathway
Core Tip	In this study, we demonstrated that insulin like growth factor 2 mRNA binding protein 2 upregulates SMAD-specific E3 ubiquitin protein ligase (SMURF) 1 expression in an N6-methyladenosine-dependent manner, and subsequently SMURF1 activates the Wnt/β-catenin-vascular endothelial growth factor signaling pathway by promoting ubiquitination and degradation of WNT inhibitory factor 1 to promote autophagy, which ultimately disrupts the tight junctions of the retinal pigment epithelium cells and thus led to diabetic macular edema.
Publish Date	2025-01-21 09:26
Citation	<p>Liang LF, Zhao JQ, Wu YF, Chen HJ, Huang T, Lu XH. SMAD specific E3 ubiquitin protein ligase 1 accelerates diabetic macular edema progression by WNT inhibitory factor 1. <i>World J Diabetes</i> 2025; 16(3): 101328</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i3/101328.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i3.101328

Full Article (PDF)	WJD-16-101328-with-cover.pdf
The ARRIVE Guidelines	101328-The-ARRIVE-Guidelines.pdf
Manuscript File	101328_Auto_Edited_080643.docx
Answering Reviewers	101328-answering-reviewers.pdf
Audio Core Tip	101328-audio.mp3
Biostatistics Review Certificate	101328-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	101328-conflict-of-interest-statement.pdf
Copyright License Agreement	101328-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101328-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	101328-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	101328-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	101328-non-native-speakers.pdf
Peer-review Report	101328-peer-reviews.pdf
Journal Editor-in-Chief Review Report	101328-journal-editor-in-chief.pdf
Scientific Misconduct Check	101328-scientific-misconduct-check.png
Scientific Editor Work List	101328-scientific-editor-work-list.pdf
CrossCheck Report	101328-crosscheck-report.pdf