| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chao Ren, Li Cha, Shu-Yue Huang, Guo-Hui Bai, Jin-Hui Li, Xin Xiong, Yu-Xing Feng, Dui-Ping Feng, Long Gao and Jin-Yu Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82200650 |
| Key Research and Development Projects of Shanxi Province |
202102130501014 |
| Natural Science Foundation of Shanxi Province |
202203021211021, 202203021212046, 20210302123258 |
|
| Corresponding Author |
Long Gao, PhD, Department of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, No. 56 Xinjian South Road, Yingze District, Taiyuan 030001, Shanxi Province, China. gaolong@sxmu.edu.cn |
| Key Words |
Hepatic encephalopathy; Total bile acid; Thioacetamide; G protein-coupled bile acid receptor 1; Liver cirrhosis |
| Core Tip |
There are many pathogenic factors for hepatic encephalopathy (HE). This experiment confirmed that total bile acids contribute to the development of HE in liver cirrhosis. The main mechanism is that bile acids mediate the expression of bile acid Takeda G protein-coupled receptor 5 in the brain and then affect microglia activation. However, this experiment only verified the role of total bile acids in HE, but there are many types of bile acids, and we still need to continue to explore in depth which bile acids play and what role they play. In short, bile acids and Takeda G protein-coupled receptor 5 in the brain may become effective targets for treating HE in the future. |
| Publish Date |
2025-03-26 04:06 |
| Citation |
<p>Ren C, Cha L, Huang SY, Bai GH, Li JH, Xiong X, Feng YX, Feng DP, Gao L, Li JY. Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats. <i>World J Hepatol</i> 2025; 17(3): 101340</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i3/101340.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i3.101340 |
