| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Neurophysiological mechanisms of electroacupuncture in regulating pancreatic function and adipose tissue expansion
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun Liu, Zhi Yu, Xuan Wang, Ming-Qian Yuan, Meng-Jiang Lu, Mei-Rong Gong, Qian Li, You-Bing Xia, Guan-Hu Yang, Bin Xu, Gerhard Litscher and Tian-Cheng Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82305376 |
| National Natural Science Foundation of China |
82374577 |
| National Natural Science Foundation of China |
82405567 |
| National Natural Science Foundation of China |
82305375 |
| National Natural Science Foundation of China |
82074532 |
| The Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) |
|
|
| Corresponding Author |
Tian-Cheng Xu, PhD, Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Insulin resistance; Electroacupuncture; Sensory nerve; Transient receptor potential vanilloid 1 receptor; Pancreatic beta cell; Peripancreatic adipose tissue |
| Core Tip |
This study underscored the pivotal role of peripancreatic adipose tissue expansion in the transition from obesity to type 2 diabetes mellitus (T2DM), influenced by the crosstalk between islet beta cells and the pancreas islet nerve system. Our findings revealed that electroacupuncture (EA), particularly when applied at ST25, effectively regulates glucolipid metabolism and pancreatic function via the TRPV1-CGRP signaling axis, thereby mitigating metabolic stress and inflammation. This provides a foundation for the development of precision therapeutic strategies for T2DM management. Ongoing exploration of the detailed mechanisms and therapeutic targets of EA at various acupoints, including LI11 and ST37, is essential for refining clinical methodologies aimed at T2DM treatment. |
| Publish Date |
2025-04-25 07:54 |
| Citation |
<p>Liu Y, Yu Z, Wang X, Yuan MQ, Lu MJ, Gong MR, Li Q, Xia YB, Yang GH, Xu B, Litscher G, Xu TC. Neurophysiological mechanisms of electroacupuncture in regulating pancreatic function and adipose tissue expansion. <i>World J Diabetes</i> 2025; 16(5): 101354</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i5/101354.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i5.101354 |
