Publication Name	World Journal of Gastroenterology
Manuscript ID	101357
Country	Italy

Received	2024-09-11 14:40
Peer-Review Started	2024-09-11 14:40
To Make the First Decision
Return for Revision	2024-12-29 01:22
Revised	2024-12-29 19:29
Second Decision	2025-01-06 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-06 05:19
Articles in Press	2025-01-06 05:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-01-11 03:59
Typeset the Manuscript	2025-01-15 08:37
Publish the Manuscript Online	2025-01-23 05:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Irritable bowel syndrome remains a complex disorder of gut-brain interaction: Too many actors on stage
Manuscript Source	Invited Manuscript
All Author List	Raffaele Pellegrino and Antonietta Gerarda Gravina
ORCID	Author(s) ORCID Number Raffaele Pellegrino http://orcid.org/0000-0001-5074-230X Antonietta Gerarda Gravina http://orcid.org/0000-0001-8049-0115
Funding Agency and Grant Number
Corresponding Author	Raffaele Pellegrino, MD, Division of Hepatogastroenterology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L De Crecchio, Naples 80138, Italy. raffaele.pellegrino@unicampania.it
Key Words	Neuroendocrine axis; Gut microbiota; Inflammatory response; Irritable bowel syndrome; Functional gastrointestinal disorders; Biopsychosocial model; Mucosal inflammation; Cytokines; Serotonergic system; Melanocortin system
Core Tip	This letter highlights the complex interplay between the neuroendocrine axis, gut microbiota, and inflammatory response in irritable bowel syndrome (IBS). By adopting a multiparametric approach, the findings proposed by the commented article suggest that IBS involves both gastrointestinal and neuroendocrine factors, supporting the biopsychosocial model for understanding and managing functional gastrointestinal disorders.
Publish Date	2025-01-23 05:47
Citation	<p>Pellegrino R, Gravina AG. Irritable bowel syndrome remains a complex disorder of gut-brain interaction: Too many actors on stage. <i>World J Gastroenterol</i> 2025; 31(8): 101357</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i8/101357.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i8.101357

Full Article (PDF)	WJG-31-101357-with-cover.pdf
Manuscript File	101357_Auto_Edited_005133.docx
Answering Reviewers	101357-answering-reviewers.pdf
Audio Core Tip	101357-audio.mp3
Conflict-of-Interest Disclosure Form	101357-conflict-of-interest-statement.pdf
Copyright License Agreement	101357-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	101357-non-native-speakers.pdf
Peer-review Report	101357-peer-reviews.pdf
Scientific Misconduct Check	101357-scientific-misconduct-check.png
Scientific Editor Work List	101357-scientific-editor-work-list.pdf
CrossCheck Report	101357-crosscheck-report.pdf