Publication Name	World Journal of Stem Cells
Manuscript ID	101376
Country	China

Received	2024-09-12 09:04
Peer-Review Started	2024-09-12 09:04
To Make the First Decision
Return for Revision	2024-11-26 10:02
Revised	2024-12-09 06:13
Second Decision	2025-03-06 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-06 07:07
Articles in Press	2025-03-06 07:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-13 09:07
Publish the Manuscript Online	2025-03-21 06:10

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pharmacology & Pharmacy
Manuscript Type	Letter to the Editor
Article Title	Cyclodextrin host-guest complex to facilitate sinomenine-based osteoporosis therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Qin Guo, Ping Hu and Zheng-Wei Huang
ORCID	Author(s) ORCID Number Zheng-Wei Huang http://orcid.org/0000-0003-2351-7347
Funding Agency and Grant Number	Funding Agency Grant Number Guangdong Basic and Applied Basic Research Foundation 2024A1515011236 General Program of Administration of Traditional Chinese Medicine of Guangdong Province 20241071
Corresponding Author	Zheng-Wei Huang, Associate Professor, PhD, College of Pharmacy, Jinan University, No. 855 East Xingye Dadao, Panyu District, Guangzhou 511443, Guangdong Province, China. huangzhengw@jnu.edu.cn
Key Words	Sinomenine; Cyclodextrin; Osteoporosis; Autophagy; Solubilization
Core Tip	Sinomenine (SIN) inhibits phosphorylation processes in the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of the rapamycin pathway, increases autophagic capacity and promotes osteogenic differentiation, hence effectively treating osteoporosis. Nevertheless, the insolubility of SIN is a limitation to its clinical application. Here, we proposed the use of host-guest inclusion instead of dimethyl sulfoxide (DMSO) to solubilise SIN by preparing SIN-β-cyclodextrin complexes. Compared with direct dissolution in DMSO, the SIN-β-cyclodextrin complexes circumvent the safety concerns associated with DMSO, providing higher water solubility, improved drug stability, lower toxicity and side effects and optimal drug release properties. We conclude the clinical application of SIN-β-cyclodextrin complexes to treat osteoporosis may be achieved.
Publish Date	2025-03-21 06:10
Citation	<p>Guo MQ, Hu P, Huang ZW. Cyclodextrin host-guest complex to facilitate sinomenine-based osteoporosis therapy. <i>World J Stem Cells</i> 2025; 17(3): 101376</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i3/101376.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i3.101376

Full Article (PDF)	WJSC-17-101376-with-cover.pdf
Manuscript File	101376_Auto_Edited_011404.docx
Answering Reviewers	101376-answering-reviewers.pdf
Audio Core Tip	101376-audio.mp3
Conflict-of-Interest Disclosure Form	101376-conflict-of-interest-statement.pdf
Copyright License Agreement	101376-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101376-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	101376-non-native-speakers.pdf
Peer-review Report	101376-peer-reviews.pdf
Scientific Misconduct Check	101376-scientific-misconduct-check.png
Scientific Editor Work List	101376-scientific-editor-work-list.pdf
CrossCheck Report	101376-crosscheck-report.pdf