Publication Name	World Journal of Gastroenterology
Manuscript ID	101380
Country	Türkiye

Received	2024-09-12 18:30
Peer-Review Started	2024-09-12 18:30
To Make the First Decision
Return for Revision	2024-09-20 19:26
Revised	2024-09-26 20:13
Second Decision	2024-10-18 01:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-18 05:38
Articles in Press	2024-10-18 05:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-10-21 21:27
Typeset the Manuscript	2024-10-31 01:09
Publish the Manuscript Online	2024-11-12 06:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Letter to the Editor
Article Title	Unveiling the intricacies of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Duygu Kirkik and Sevgi Kalkanli Tas
ORCID	Author(s) ORCID Number Duygu Kirkik http://orcid.org/0000-0003-1417-6915 Sevgi Kalkanli Tas http://orcid.org/0000-0001-5288-6040
Funding Agency and Grant Number
Corresponding Author	Duygu Kirkik, PhD, Assistant Professor, Department of Immunology, University of Health Sciences, Hamidiye Medicine Faculty, Mekteb-i Tıbbiyye-i Şâhane (Haydarpaşa) Külliyesi Selimiye Mah. Tıbbiye Cad. No:38 34668 Üsküdar, Istanbul 34668, Türkiye. dygkirkik@gmail.com
Key Words	Gastrointestinal symptoms; Inflammatory response; Intestinal microbiota; Irritable bowel syndrome; Neuroendocrine axis
Core Tip	This letter provides a comprehensive review of the interaction between the neuroendocrine axis, gut microbiota, and inflammation plays a pivotal role in the development of irritable bowel syndrome (IBS). This study reveals that imbalances in these systems, such as elevated stress hormones and altered microbial populations, exacerbate IBS symptoms. Targeted therapeutic approaches that modulate these interconnected pathways may offer new hope for personalized treatment options.
Publish Date	2024-11-12 06:08
Citation	<p>Kirkik D, Kalkanli Tas S. Unveiling the intricacies of irritable bowel syndrome. <i>World J Gastroenterol</i> 2024; 30(44): 4763-4767</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i44/4763.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i44.4763

Full Article (PDF)	WJG-30-4763-with-cover.pdf
Manuscript File	101380_Auto_Edited_012923.docx
Answering Reviewers	101380-answering-reviewers.pdf
Audio Core Tip	101380-audio.mp3
Conflict-of-Interest Disclosure Form	101380-conflict-of-interest-statement.pdf
Copyright License Agreement	101380-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	101380-non-native-speakers.pdf
Peer-review Report	101380-peer-reviews.pdf
Scientific Misconduct Check	101380-scientific-misconduct-check.png
Scientific Editor Work List	101380-scientific-editor-work-list.pdf
CrossCheck Report	101380-crosscheck-report.png
CrossCheck Report	101380-crosscheck-report.pdf