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Articles Published Processes
2/24/2025 5:39:23 AM | Browse: 144 | Download: 460
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Received |
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2024-11-28 07:57 |
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Peer-Review Started |
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2024-11-28 07:57 |
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First Decision by Editorial Office Director |
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2024-12-18 10:28 |
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Return for Revision |
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2024-12-18 10:28 |
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Revised |
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2024-12-27 14:34 |
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Publication Fee Transferred |
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2024-12-31 06:46 |
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Second Decision by Editor |
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2025-02-10 02:13 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-02-11 08:31 |
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Articles in Press |
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2025-02-11 08:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-02-17 03:19 |
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Publish the Manuscript Online |
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2025-02-24 05:39 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomal miR-203 from bone marrow stem cells targets the SOCS3/NF-κB pathway to regulate neuroinflammation in temporal lobe epilepsy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Wang and Jian Yin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jian Yin, Chief Physician, PhD, Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. yin_dmu@sina.com |
| Key Words |
Epilepsy; Neuroinflammation; MiR-203; Exosomes; Bone marrow mesenchymal stem cells; Suppressor of cytokine signaling; Nuclear factor kappaB |
| Core Tip |
This study highlights the role of bone marrow mesenchymal stem cell-derived exosomal miR-203 in regulating neuroinflammation in a mouse model of temporal lobe epilepsy. These findings suggest that miR-203 modulates the suppressor of cytokine signaling 3/nuclear factor kappaB pathway, leading to increased neuroinflammation. This pathway activation promotes the secretion of proinflammatory cytokines, contributing to the pathology of epilepsy. Targeting miR-203 may offer a novel therapeutic approach for drug-resistant epilepsy by reducing neuroinflammation and improving patient outcomes, offering potential for future cell-free therapeutic strategies. |
| Publish Date |
2025-02-24 05:39 |
| Citation |
Wang W, Yin J. Exosomal miR-203 from bone marrow stem cells targets the SOCS3/NF-κB pathway to regulate neuroinflammation in temporal lobe epilepsy. World J Stem Cells 2025; 17(2): 101395 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i2/101395.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i2.101395 |
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