Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	101403
Country	China

Received	2024-09-13 06:42
Peer-Review Started	2024-09-13 06:42
To Make the First Decision
Return for Revision	2024-10-29 09:40
Revised	2024-11-07 10:07
Second Decision	2024-12-03 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-03 07:11
Articles in Press	2024-12-03 07:11
Publication Fee Transferred	2024-11-09 11:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-27 01:25
Publish the Manuscript Online	2025-01-22 09:25

ISSN	1948-9366 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Value of brief hematological characteristics in differentiating carcinoembryonic-antigen-negative colorectal cancer from benign colorectal diseases
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Ling Yi, Xian-Jun Lao, Liu-Yi Lu, Chun-Ling Zhu, Dong-Yi Zhou, Si-Ting Li, Meng-Li Fan and Qi-Liu Peng
ORCID	Author(s) ORCID Number Li-Ling Yi http://orcid.org/0009-0003-9994-3542 Xian-Jun Lao http://orcid.org/0009-0009-0911-0330 Liu-Yi Lu http://orcid.org/0000-0002-0966-2233 Chun-Ling Zhu http://orcid.org/0009-0007-4195-0458 Dong-Yi Zhou http://orcid.org/0000-0002-9279-5394 Si-Ting Li http://orcid.org/0009-0005-6316-7697 Meng-Li Fan http://orcid.org/0009-0003-6203-4863 Qi-Liu Peng http://orcid.org/0000-0001-7294-8640
Funding Agency and Grant Number	Funding Agency Grant Number Youth Project of Guangxi International Zhuang Medicine Hospital [2022]203 Discipline Project of Guangxi International Zhuang Medicine Hospital [2021]33 Research Fund of Guangxi International Zhuang Medicine Hospital RCYJ202201
Corresponding Author	Qi-Liu Peng, PhD, Professor, Department of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, No. 8 Qiuyue Road, Liangqing District, Nanning 530201, Guangxi Zhuang Autonomous Region, China. pengql45@163.com
Key Words	Hematological parameters; Carcinoembryonic-antigen-negative; Colorectal cancer; Biomarkers; Inflammatory cell ratios
Core Tip	A retrospective analysis was used to investigate the hematological characteristics of carcinoembryonic-antigen (CEA)-negative colorectal cancer (CRC) with the aim of identifying potentially valuable biomarkers for distinguishing between CEA-negative CRC and benign colorectal diseases. We found that hematological parameters were associated with CEA-negative CRC and benign colorectal diseases. Moreover, hematological ratios were related to clinicopathological features of CEA-negative CRC. The results suggest that hemoglobin-to-red blood cell distribution width ratio, lymphocyte-to-red blood cell distribution width ratio, and platelet-to-lymphocyte ratio either individually or in combination could effectively differentiate CEA-negative CRC from benign colorectal diseases.
Publish Date	2025-01-22 09:25
Citation	<p>Yi LL, Lao XJ, Lu LY, Zhu CL, Zhou DY, Li ST, Fan ML, Peng QL. Value of brief hematological characteristics in differentiating carcinoembryonic-antigen-negative colorectal cancer from benign colorectal diseases. <i>World J Gastrointest Surg</i> 2025; 17(2): 101403</p>
URL	https://www.wjgnet.com/1948-9366/full/v17/i2/101403.htm
DOI	https://dx.doi.org/10.4240/wjgs.v17.i2.101403

Full Article (PDF)	WJGS-17-101403-with-cover.pdf
Manuscript File	101403_Auto_Edited_013618.docx
Answering Reviewers	101403-answering-reviewers.pdf
Audio Core Tip	101403-audio.mp3
Biostatistics Review Certificate	101403-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	101403-conflict-of-interest-statement.pdf
Copyright License Agreement	101403-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101403-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	101403-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	101403-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	101403-non-native-speakers.pdf
Peer-review Report	101403-peer-reviews.pdf
Scientific Misconduct Check	101403-scientific-misconduct-check.png
Scientific Editor Work List	101403-scientific-editor-work-list.pdf
CrossCheck Report	101403-crosscheck-report.pdf