Publication Name	World Journal of Orthopedics
Manuscript ID	101424
Country	China

Received	2024-09-13 15:43
Peer-Review Started	2024-09-13 15:43
To Make the First Decision
Return for Revision	2024-10-24 13:58
Revised	2024-11-03 14:37
Second Decision	2024-12-19 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-19 08:26
Articles in Press	2024-12-19 08:26
Publication Fee Transferred	2024-11-05 10:33
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-31 01:11
Publish the Manuscript Online	2025-01-13 08:26

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Comparative study of a rabbit model of spinal tuberculosis using different concentrations of Mycobacterium tuberculosis
Manuscript Source	Unsolicited Manuscript
All Author List	Yong-Jie Qiao, Xiao-Yang Song, Lv-Dan Zhang, Feng Li, Hao-Qiang Zhang and Sheng-Hu Zhou
ORCID	Author(s) ORCID Number Yong-Jie Qiao http://orcid.org/0000-0001-7335-9020 Xiao-Yang Song http://orcid.org/0000-0002-5851-3269 Feng Li http://orcid.org/0000-0002-0763-014X Hao-Qiang Zhang http://orcid.org/0000-0001-5593-7974 Sheng-Hu Zhou http://orcid.org/0000-0002-4539-319X
Funding Agency and Grant Number	Funding Agency Grant Number Lanzhou City Science and Technology Development Guiding Plan Project 2023-ZD-170 Lanzhou Science and Technology Plan Project 2023-2-11 High-Level Talent Training Project At the 940th Hospital of the Joint Logistics Force 2024-G3-5
Corresponding Author	Sheng-Hu Zhou, Associate Chief Physician, PhD, Department of Orthopedics, The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army, No. 333 South Riverside Road, Lanzhou 730000, Gansu Province, China. zhoushenghu120@163.com
Key Words	Spinal tuberculosis; Animal model; H37RV; Mycobacterium tuberculosis; New Zealand rabbits
Core Tip	One study reported having established osteoarticular tuberculosis using non-sensitized animals; however, the result of the experiment was unsatisfactory because of the high mortality rate. In recent studies, Liu X and Guangqi Geng successfully established a spinal tuberculosis model in New Zealand rabbits after sensitizing the rabbits with complete Freund’s adjuvant(9-11). However, they established the model without making a comparative study of the effect of using different bacterial concentrations. In this study, we established a model using three concentrations of bacteria and carried out a comprehensive evaluation of the model by imaging, general observations, and histopathological and bacteriological studies.
Publish Date	2025-01-13 08:26
Citation	<p>Qiao YJ, Song XY, Zhang LD, Li F, Zhang HQ, Zhou SH. Comparative study of a rabbit model of spinal tuberculosis using different concentrations of Mycobacterium tuberculosis. <i>World J Orthop</i> 2025; 16(1): 101424</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i1/101424.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i1.101424

Full Article (PDF)	WJO-16-101424-with-cover.pdf
The ARRIVE Guidelines	101424-The-ARRIVE-Guidelines.pdf
Manuscript File	101424_Auto_Edited_033036.docx
Answering Reviewers	101424-answering-reviewers.pdf
Audio Core Tip	101424-audio.m4a
Biostatistics Review Certificate	101424-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	101424-conflict-of-interest-statement.pdf
Copyright License Agreement	101424-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101424-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	101424-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	101424-non-native-speakers.pdf
Peer-review Report	101424-peer-reviews.pdf
Scientific Misconduct Check	101424-scientific-misconduct-check.png
Scientific Editor Work List	101424-scientific-editor-work-list.pdf
CrossCheck Report	101424-crosscheck-report.png
CrossCheck Report	101424-crosscheck-report.pdf