| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Impaired efferocytosis by monocytes and monocyte-derived macrophages in patients with poorly controlled type 2 diabetes
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qian-Yun Mao, Hui Ran, Qiu-Yue Hu, Sun-Yue He, Yao Lu, Han Li, Yi-Meng Chai, Zhao-Yin Chu, Xu Qian, Wan Ding, Yi-Xin Niu, Hong-Mei Zhang, Xiao-Yong Li and Qing Su |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China Research |
81970669, 82170835, and 82100848 |
| Shanghai Municipal Health Commission |
202240107, and 20234Y0040 |
| China Endocrine Metabolism Research Program of Excellence |
2023-N-03-05 |
|
| Corresponding Author |
Qing Su, MD, PhD, Professor, Department of Endocrinology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, No. 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. suqing@xinhuamed.com.cn |
| Key Words |
Type 2 diabetes; Efferocytosis; Monocyte; Macrophage |
| Core Tip |
This study compared the efferocytosis function of blood monocytes and monocyte-derived macrophages in type 2 diabetes (T2D) patients with poor glycemic control. The results revealed that both monocytes and macrophages exhibited impaired efferocytosis. Additionally, the percentages of classical monocytes (CD14++CD16- monocytes) and CD14+ macrophages were significantly lower in the diabetes group. Multivariate linear regression analysis demonstrated that the monocyte efferocytosis index was independently associated with both the glycosylated hemoglobin level and the macrophage efferocytosis index showed a significant association with the percentage of CD14+ macrophages. These findings suggest that glucotoxicity may impact efferocytosis by reducing CD14 expression on both monocytes and macrophages in T2D patients. |
| Publish Date |
2025-04-25 07:53 |
| Citation |
<p>Mao QY, Ran H, Hu QY, He SY, Lu Y, Li H, Chai YM, Chu ZY, Qian X, Ding W, Niu YX, Zhang HM, Li XY, Su Q. Impaired efferocytosis by monocytes and monocyte-derived macrophages in patients with poorly controlled type 2 diabetes. <i>World J Diabetes</i> 2025; 16(5): 101473</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i5/101473.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i5.101473 |
