Publication Name	World Journal of Stem Cells
Manuscript ID	101485
Country	South Korea

Received	2024-09-16 05:21
Peer-Review Started	2024-09-16 05:21
To Make the First Decision
Return for Revision	2024-10-30 09:50
Revised	2024-11-11 05:55
Second Decision	2024-12-16 02:15
Accepted by Journal Editor-in-Chief	2024-12-16 22:10
Accepted by Executive Editor-in-Chief	2025-01-08 01:23
Articles in Press	2025-01-08 01:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-11 10:06
Publish the Manuscript Online	2025-01-20 02:39

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Extended protective effects of three dimensional cultured human mesenchymal stromal cells in a neuroinflammation model
Manuscript Source	Unsolicited Manuscript
All Author List	Ok-Hyeon Kim, Hana Kang, Eun Seo Chang, Younghyun Lim, Young-Jin Seo and Hyun Jung Lee
ORCID	Author(s) ORCID Number Hyun Jung Lee http://orcid.org/0000-0002-9941-9826
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea RS-2024-00409554, 2023R1A2C2006894 National Research Foundation of Korea 2021R1A6A3A01088243
Corresponding Author	Hyun Jung Lee, PhD, Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul 06974, South Korea. pluto38@cau.ac.kr
Key Words	Mesenchymal stromal cells; Three-dimensional culture; Immunomodulatory function; Neuroinflammation; Cell therapy
Core Tip	Clinical trials utilizing mesenchymal stromal cells (MSCs) have been on the rise, but several barriers to broader adoption of MSCs as therapeutics remain to be addressed. Our study presents compelling evidence demonstrating the remarkable enhancement of immunomodulatory capabilities in functional polymer-based MSCs through three-dimensional culture. We specifically applied these optimized MSCs to a brain inflammation model and found a prolonged and more potent anti-inflammatory effect in vivo compared to conventionally cultured MSCs. The polymer-based three-dimensional cultures we propose could be an easy tool for mass culture for clinical applications.
Publish Date	2025-01-20 02:39
Citation	<p>Kim OH, Kang H, Chang ES, Lim Y, Seo YJ, Lee HJ. Extended protective effects of three dimensional cultured human mesenchymal stromal cells in a neuroinflammation model. <i>World J Stem Cells</i> 2025; 17(1): 101485</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i1/101485.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i1.101485

Full Article (PDF)	WJSC-17-101485-with-cover.pdf
The ARRIVE Guidelines	101485-The-ARRIVE-Guidelines.pdf
Manuscript File	101485_Auto_Edited_011722.docx
Answering Reviewers	101485-answering-reviewers.pdf
Audio Core Tip	101485-audio.mp3
Biostatistics Review Certificate	101485-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	101485-conflict-of-interest-statement.pdf
Copyright License Agreement	101485-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101485-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	101485-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	101485-non-native-speakers.pdf
Supplementary Material	101485-supplementary-material.pdf
Peer-review Report	101485-peer-reviews.pdf
Journal Editor-in-Chief Review Report	101485-journal-editor-in-chief.pdf
Scientific Misconduct Check	101485-scientific-misconduct-check.png
Scientific Editor Work List	101485-scientific-editor-work-list.pdf
CrossCheck Report	101485-crosscheck-report.pdf