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Articles Published Processes
1/21/2025 6:56:33 AM | Browse: 59 | Download: 375
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Received |
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2024-09-19 12:29 |
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Peer-Review Started |
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2024-09-19 12:29 |
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First Decision by Editorial Office Director |
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2024-10-24 09:34 |
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Return for Revision |
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2024-10-24 09:34 |
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Revised |
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2024-11-02 09:52 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-12-17 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-12-17 09:04 |
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Articles in Press |
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2024-12-17 09:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-12-31 01:05 |
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Publish the Manuscript Online |
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2025-01-21 06:56 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Respiratory System |
| Manuscript Type |
Review |
| Article Title |
Impact of sodium-glucose cotransporter-2 inhibitors on pulmonary vascular cell function and arterial remodeling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Jing Zhang, Xue-Rui Ye, Xue-Song Liu, Hao-Ling Zhang and Qian Qiao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Department of Yunnan Province - Kunming Medical University, Kunming Medical Joint Special Project - Surface Project |
202401AY070001-164 |
| Yunnan Provincial Clinical Research Center Cardiovascular Diseases - New Technology Research for Development Project for Diagnosis and Treatment Cardiovascular Diseases |
202102AA310002 |
| Key Technology Research and Device Development Project for Innovative Diagnosis and Treatment of Structural Heart Disease in the Southwest Plateau Region |
202302AA310045 |
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| Corresponding Author |
Qian Qiao, PhD, Professor, Chinese Academy Medical Sciences, Fuwai Yunnan Hospital, No. 528 Shahe North Road, Northwest New District, Wuhua District, Kunming 650000, Yunnan Province, China. qiaoqian1102@163.com |
| Key Words |
Sodium-glucose cotransporter-2 inhibitors; Pulmonary vascular endothelial cells; Pulmonary vascular smooth muscle cells; Pulmonary artery remodeling; Right heart dysfunction; Cardiovascular disease |
| Core Tip |
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are innovative antidiabetic agents that lower blood glucose by promoting its excretion via the kidneys. Beyond their glucose-lowering effects, SGLT2 inhibitors have demonstrated significant cardiovascular benefits in clinical trials. Emerging basic science research indicates that SGLT2 inhibitors also positively impact pulmonary vascular health. They enhance the function of pulmonary vascular endothelial cells, inhibit the proliferation and migration of pulmonary smooth muscle cells, reverse pulmonary arterial remodeling, and help maintain hemodynamic stability. This review consolidates current findings on the mechanisms by which SGLT2 inhibitors improve pulmonary vascular cell function and arterial remodeling, suggesting new therapeutic possibilities for pulmonary vascular diseases. |
| Publish Date |
2025-01-21 06:56 |
| Citation |
Zhang JJ, Ye XR, Liu XS, Zhang HL, Qiao Q. Impact of sodium-glucose cotransporter-2 inhibitors on pulmonary vascular cell function and arterial remodeling. World J Cardiol 2025; 17(1): 101491 |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i1/101491.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i1.101491 |
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