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Articles Published Processes
11/29/2024 2:50:18 PM | Browse: 189 | Download: 700
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Received |
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2024-09-19 00:30 |
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Peer-Review Started |
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2024-09-19 02:21 |
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First Decision by Editorial Office Director |
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2024-10-09 03:36 |
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Return for Revision |
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2024-10-09 03:36 |
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Revised |
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2024-10-15 14:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-10-29 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-29 11:29 |
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Articles in Press |
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2024-10-29 11:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-10-31 12:33 |
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Publish the Manuscript Online |
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2024-11-29 14:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Agriculture, Dairy & Animal Science |
| Manuscript Type |
Editorial |
| Article Title |
Targeting hypoxia and angiogenesis in hepatocellular carcinoma: New insights and therapeutic strategies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia-Yi Du, Chu-Ting Zhang, Ting Li and Ya-Ping Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ya-Ping Li, MD, PhD, Department of Infectious Diseases, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 West 5th Road, Xincheng District, Xi’an 710004, Shaanxi Province, China. liyaping8605@xjtu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Hypoxia-inducible factor-1α; Angiopoietin-2; Angiogenesis; Tumor microenvironment |
| Core Tip |
In hepatocellular carcinoma (HCC) progression, hypoxia-inducible factor-1α (HIF-1α) promotes tumor angiogenesis, invasion, and metastasis by upregulating angiopoietin-2 (Ang-2), particularly within the hypoxic microenvironment. The synergistic interaction between HIF-1α and Ang-2 not only facilitates tumor cell epithelial-mesenchymal transition but may also contribute to multidrug resistance. Therefore, targeting the HIF-1α/Ang-2 axis holds promise as a therapeutic strategy to inhibit HCC metastasis and improve patient prognosis. Moreover, Ang-2 may serve as a potential biomarker for early HCC diagnosis and progression monitoring. |
| Publish Date |
2024-11-29 14:50 |
| Citation |
Du JY, Zhang CT, Li T, Li YP. Targeting hypoxia and angiogenesis in hepatocellular carcinoma: New insights and therapeutic strategies. World J Hepatol 2024; 16(12): 1371-1376 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i12/1371.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i12.1371 |
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