Publication Name	World Journal of Critical Care Medicine
Manuscript ID	101499
Country	United States

Received	2024-09-16 15:58
Peer-Review Started	2024-09-16 15:58
To Make the First Decision
Return for Revision	2024-10-14 03:39
Revised	2024-10-22 03:44
Second Decision	2024-11-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-12 09:19
Articles in Press	2024-11-12 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-15 10:50
Publish the Manuscript Online	2024-12-11 10:54

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Targeting sepsis through inflammation and oxidative metabolism
Manuscript Source	Invited Manuscript
All Author List	Salena Jacob, Sanjana Ann Jacob and Joby Thoppil
ORCID	Author(s) ORCID Number Joby Thoppil http://orcid.org/0000-0002-3722-3369
Funding Agency and Grant Number
Corresponding Author	Joby Thoppil, Assistant Professor, MD, PhD, Emergency Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd E6.110A, Dallas, TX 75390, United States. joby.thoppil@utsouthwestern.edu
Key Words	Sepsis; Inflammation; Oxidative Metabolism; Infection; Reactive oxygen species
Core Tip	The need for better diagnostic tests and treatments has been voiced for infectious diseases in general with special emphasis on sepsis. The current state of sepsis treatment revolves around antibiotics and supportive measures. Understanding sepsis pathophysiology is crucial to identifying effective therapies to support the immune system, thereby preventing disease progression and organ dysfunction. Discovering novel strategies for immune augmentation may be the key to successfully treating sepsis. Moving forward, it is crucial to continue investigating the mechanisms of action of these therapeutics, conducting rigorous large-scale clinical trials, and refining treatment strategies to enhance sepsis outcomes.
Publish Date	2024-12-11 10:54
Citation	<p>Jacob S, Jacob SA, Thoppil J. Targeting sepsis through inflammation and oxidative metabolism. <i>World J Crit Care Med</i> 2025; 14(1): 101499</p>
URL	https://www.wjgnet.com/2220-3141/full/v14/i1/101499.htm
DOI	https://dx.doi.org/10.5492/wjccm.v14.i1.101499

Full Article (PDF)	WJCCM-14-101499-with-cover.pdf
Manuscript File	101499_Auto_Edited_025151.docx
Answering Reviewers	101499-answering-reviewers.pdf
Audio Core Tip	101499-audio.mp3
Conflict-of-Interest Disclosure Form	101499-conflict-of-interest-statement.pdf
Copyright License Agreement	101499-copyright-assignment.pdf
Peer-review Report	101499-peer-reviews.pdf
Scientific Misconduct Check	101499-scientific-misconduct-check.png
Scientific Editor Work List	101499-scientific-editor-work-list.pdf
CrossCheck Report	101499-crosscheck-report.pdf