Publication Name	World Journal of Gastroenterology
Manuscript ID	10154
Country	Greece

Received	2014-03-16 18:22
Peer-Review Started	2014-03-16 23:38
To Make the First Decision	2014-04-15 20:02
Return for Revision	2014-04-23 19:08
Revised	2014-05-21 00:00
Second Decision	2014-06-17 09:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-17 09:53
Articles in Press	2014-06-17 10:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-20 15:46
Publish the Manuscript Online	2014-11-10 19:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Immune-modulating therapy in acute pancreatitis: Fact or fiction
Manuscript Source	Invited Manuscript
All Author List	Karolina Akinosoglou and Charalambos Gogos
Funding Agency and Grant Number
Corresponding Author	Karolina Akinosoglou, MD, Department of Internal Medicine and Infectious Diseases, University General Hospital of Patras, 5th Floor, 26504 Rio, Greece. akin@upatras.gr
Key Words	Acute pancreatitis; Immune-modulation; Systemic inflammatory response syndrome; Multiple organ dysfunction syndrome; Endoscopic retrograde cholangiopancreatography
Core Tip	Acute pancreatitis is a common entity with significant mortality worldwide. Treatment remains non-specific and mainly supportive, mostly focusing on intensive care. Presence of inflammatory response syndrome during AP has driven recent immune-modulating therapeutic attempts in experimental models, including cytokine, chemokine, immune cell and other inflammatory mediator blockade. Although initial data are promising, translation to clinical routine has been less encouraging. The authors attempt to elucidate whether and to what extent tampering with the immune burst triggered by acute pancreatitis could actually ensure better outcomes, or that remains a farfetched expectation.
Publish Date	2014-11-10 19:10
Citation	Akinosoglou K, Gogos C. Immune-modulating therapy in acute pancreatitis: Fact or fiction. World J Gastroenterol 2014; 20(41): 15200-15215
URL	http://www.wjgnet.com/1007-9327/full/v20/i41/15200.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i41.15200

Full Article (PDF)	WJG-20-15200.pdf
Full Article (Word)	WJG-20-15200.doc
Manuscript File	10154-Review.docx
Answering Reviewers	10154-Answering reviewers.pdf
Non-Native Speakers of English Editing Certificate	10154-Language certificate.pdf
Peer-review Report	10154-Peer reviews.pdf
Scientific Misconduct Check	10154-CrossCheck.jpg
Scientific Editor Work List	10154-Scientific editor work list.pdf