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Articles Published Processes
1/23/2025 5:47:37 AM | Browse: 48 | Download: 130
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Received |
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2024-09-19 18:51 |
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Peer-Review Started |
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2024-09-19 18:51 |
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To Make the First Decision |
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Return for Revision |
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2024-11-26 03:51 |
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Revised |
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2024-12-04 03:53 |
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Second Decision |
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2025-01-06 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-01-06 05:43 |
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Articles in Press |
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2025-01-06 05:43 |
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Publication Fee Transferred |
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2024-12-06 01:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-01-17 00:23 |
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Publish the Manuscript Online |
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2025-01-23 05:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Ras-related protein Rab24 plays a predictive role in hepatocellular carcinoma and enhanced tumor proliferation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Han Ding, Zhi-Guo Ding, Song Liu, Xu-Nan Mao and Xing-Sheng Lu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xing-Sheng Lu, MD, Department of General Surgery, The Fourth Affiliated Hospital of Soochow University, No. 9 Chongwen Road, Suzhou 215000, Jiangsu Province, China. luxingsheng88@sina.com |
| Key Words |
Hepatocellular carcinoma; Ras-related protein; Rab24; Prognosis; Proliferation |
| Core Tip |
This is a basic study to identify clinical significance and tumor related effects of ras-related protein Rab24 in hepatocellular carcinoma (HCC). High expression of Rab24 was significantly associated with larger tumor, advanced tumor stage and poorer overall survival. By using overexpression and shRNA knockdown strategies in HCC cell lines, we found that Rab24 can promote HCC proliferation. Finally, we validated that silencing Rab24 significantly attenuated xenograft growth in vivo. Our study firstly demonstrated that high expression of Rab24 was significantly correlated with poorer prognosis of HCC patients, indicating the potential of Rab24 as a novel clinical biomarker and therapeutic target. |
| Publish Date |
2025-01-23 05:47 |
| Citation |
<p>Ding H, Ding ZG, Liu S, Mao XN, Lu XS. Ras-related protein Rab24 plays a predictive role in hepatocellular carcinoma and enhanced tumor proliferation. <i>World J Gastroenterol</i> 2025; 31(8): 101585</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i8/101585.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i8.101585 |
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