Publication Name	World Journal of Critical Care Medicine
Manuscript ID	101587
Country	India

Received	2024-09-19 15:29
Peer-Review Started	2024-09-19 15:29
To Make the First Decision
Return for Revision	2025-01-12 08:39
Revised	2025-01-19 18:52
Second Decision	2025-02-12 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-12 09:07
Articles in Press	2025-02-12 09:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-21 02:02
Publish the Manuscript Online	2025-02-27 08:55

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Sepsis in liver failure patients: Diagnostic challenges and recent advancements
Manuscript Source	Invited Manuscript
All Author List	Ramesh Kumar, Abhishek Kumar and Sudhir Kumar
ORCID	Author(s) ORCID Number Ramesh Kumar http://orcid.org/0000-0001-5136-4865 Sudhir Kumar http://orcid.org/0000-0001-7117-1382
Funding Agency and Grant Number
Corresponding Author	Ramesh Kumar, MD, Department of Gastroenterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, Bihar, India. docrameshkr@gmail.com
Key Words	Liver failure; Sepsis; Bacterial infection; Acute liver failure; Acute-on-chronic liver failure
Core Tip	Patients with liver failure (LF) are prone to bacterial sepsis due to immune dysregulation. Up to 80% of such patients develop bacterial infection, which is associated with various complications and poor outcomes. Therefore, it is imperative to diagnose bacterial sepsis at the earliest. However, differentiating between patients with and without sepsis can be challenging, as LF itself can mimic sepsis by inducing systemic inflammation and organ failure. Several novel biomarkers for sepsis and machine learning techniques are being investigated, as conventional biomarkers have shown inconsistent results in LF patients. This article addresses the magnitude, impact, challenges, and recent developments in understanding bacterial sepsis in LF patients.
Publish Date	2025-02-27 08:55
Citation	<p>Kumar R, Kumar A, Kumar S. Sepsis in liver failure patients: Diagnostic challenges and recent advancements. <i>World J Crit Care Med</i> 2025; 14(2): 101587</p>
URL	https://www.wjgnet.com/2220-3141/full/v14/i2/101587.htm
DOI	https://dx.doi.org/10.5492/wjccm.v14.i2.101587

Full Article (PDF)	WJCCM-14-101587-with-cover.pdf
Manuscript File	101587_Auto_Edited_055300.docx
Answering Reviewers	101587-answering-reviewers.pdf
Audio Core Tip	101587-audio.mp3
Conflict-of-Interest Disclosure Form	101587-conflict-of-interest-statement.pdf
Copyright License Agreement	101587-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	101587-non-native-speakers.pdf
Peer-review Report	101587-peer-reviews.pdf
Scientific Misconduct Check	101587-scientific-misconduct-check.png
Scientific Editor Work List	101587-scientific-editor-work-list.pdf
CrossCheck Report	101587-crosscheck-report.pdf