Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	101618
Country	China

Received	2024-09-20 14:59
Peer-Review Started	2024-09-20 14:59
To Make the First Decision
Return for Revision	2025-01-04 06:42
Revised	2025-01-17 05:38
Second Decision	2025-04-10 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-11 01:35
Articles in Press	2025-04-11 01:35
Publication Fee Transferred	2025-02-09 07:41
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-29 09:54
Publish the Manuscript Online	2025-05-12 03:57

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Diverse phenotypic manifestations of small intestinal mucosa in non-infectious common variable immunodeficiency bowel disease: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Tian He, Min-Min Fan, Peng-Qiong Zhang, Wen Zhang, Dong Fan, Liu-Suo Du, Ming Tang, Ping Wan and Zheng-Ji Song
ORCID	Author(s) ORCID Number Peng-Qiong Zhang http://orcid.org/0009-0006-8782-7669 Wen Zhang http://orcid.org/0000-0002-0825-1440 Zheng-Ji Song http://orcid.org/0000-0002-6297-0497
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82360120 Ten Thousand Doctor Plan in Yunnan Province YNWR-MY-2018-020 Yunnan Provincial Key Laboratory of Clinical Virology 202205AG070053-07
Corresponding Author	Zheng-Ji Song, Department of Gastroenterology, The First People's Hospital of Yunnan Province, No. 157 Jinbi Road, Xishan District, Kunming 650032, Yunnan Province, China. song4715@163.com
Key Words	Diverse phenotypic manifestations; Common variant immunodeficiency disease; Double balloon-assisted enteroscopy; Inflammatory bowel disease; IgG; Case report
Core Tip	We report a case of non-infectious common variable immunodeficiency (CVID) patient associated bowel disease with non-specific clinical manifestations, which is characterized by B-cell dysfunction and reduced levels of serum IgG. The disease is rare and the etiology and pathogenesis remain unknown, making it difficult to diagnose, thus resulting in high mortality. Whole small intestinal double balloon enteroscopy is helpful for early diagnosis and reveals the involvement of the whole small intestinal mucosa. This case emphasizes that timely diagnosis, effective intervention and follow-up management are essential to improve the outcome of CVID patients.
Publish Date	2025-05-12 03:57
Citation	<p>He T, Fan MM, Zhang PQ, Zhang W, Fan D, Du LS, Tang M, Wan P, Song ZJ. Diverse phenotypic manifestations of small intestinal mucosa in non-infectious common variable immunodeficiency bowel disease: A case report. <i>World J Gastrointest Endosc</i> 2025; 17(5): 101618</p>
URL	https://www.wjgnet.com/1948-5190/full/v17/i5/101618.htm
DOI	https://dx.doi.org/10.4253/wjge.v17.i5.101618

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