Publication Name	World Journal of Psychiatry
Manuscript ID	101658
Country	China

Received	2024-09-22 13:43
Peer-Review Started	2024-09-22 13:43
To Make the First Decision
Return for Revision	2025-01-03 09:02
Revised	2025-04-10 03:35
Second Decision	2025-08-07 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-07 08:15
Articles in Press	2025-08-07 08:15
Publication Fee Transferred	2025-04-25 07:07
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-15 03:23
Publish the Manuscript Online	2025-09-26 08:19

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Psychology, Applied
Manuscript Type	Randomized Controlled Trial
Article Title	Enhancing schizophrenia treatment efficacy: The combined impact of Yueju pill and olanzapine through quercetin target modulation
Manuscript Source	Unsolicited Manuscript
All Author List	Dian-Ming Zhu, Ying Lu, Xu-Dong Xiao, Yang Sun, Gang Tao, Bin Long and Jing Zhao
ORCID	Author(s) ORCID Number Dian-Ming Zhu http://orcid.org/0009-0007-1914-7669 Gang Tao http://orcid.org/0009-0007-8849-9975
Funding Agency and Grant Number
Corresponding Author	Jing Zhao, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Traditional Chinese Medicine for Mental Health, No. 3210 Humin Road, Minhang District, Shanghai 201108, China. 1809020220@stu.hrbust.edu.cn
Key Words	Schizophrenia; Yueju pill; Olanzapine; Quercetin; Dopamine pathway; Network pharmacology; Brain-derived neurotrophic factor; Cognitive function
Core Tip	This study is the first to report the mechanism of Yueju pill combined with olanzapine in the treatment of schizophrenia. This study finds that Yueju pill combined with olanzapine does not increase adverse effects in the treatment of schizophrenia, demonstrating its safety. This study reveals the association between the upregulation of serum brain-derived neurotrophic factor, dopamine (DA), and serotonin levels and the therapeutic effects of Yueju pill combined with olanzapine in treating schizophrenia. This study preliminarily elucidates the therapeutic targets of Yueju pill through network pharmacology. This study identifies key genes related to the DA pathway, providing new theoretical foundations and molecular targets for the diagnosis and treatment of schizophrenia.
Publish Date	2025-09-26 08:19
Citation	<p>Zhu DM, Lu Y, Xiao XD, Sun Y, Tao G, Long B, Zhao J. Enhancing schizophrenia treatment efficacy: The combined impact of Yueju pill and olanzapine through quercetin target modulation. <i>World J Psychiatry</i> 2025; 15(10): 101658</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i10/101658.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i10.101658

Full Article (PDF)	WJP-15-101658-with-cover.pdf
CONSORT 2010 Statement	101658-CONSORT-2010-statement.pdf
Manuscript File	101658_Auto_Edited_061007.docx
Answering Reviewers	101658-answering-reviewers.pdf
Audio Core Tip	101658-audio.WAV
Biostatistics Review Certificate	101658-biostatistics-statement.pdf
Clinical Trial Registration Statement	101658-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	101658-conflict-of-interest-statement.pdf
Copyright License Agreement	101658-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	101658-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	101658-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	101658-non-native-speakers.pdf
Supplementary Material	101658-supplementary-material.pdf
Peer-review Report	101658-peer-reviews.pdf
Scientific Misconduct Check	101658-scientific-misconduct-check.png
Scientific Editor Work List	101658-scientific-editor-work-list.pdf
CrossCheck Report	101658-crosscheck-report.pdf