Publication Name	World Journal of Clinical Cases
Manuscript ID	101665
Country	China

Received	2024-09-25 13:46
Peer-Review Started	2024-09-25 13:46
To Make the First Decision
Return for Revision	2024-11-25 10:34
Revised	2024-12-06 14:26
Second Decision	2025-01-10 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-11 09:08
Articles in Press	2025-01-11 09:08
Publication Fee Transferred	2024-12-11 08:04
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-16 09:26
Publish the Manuscript Online	2025-02-10 07:51

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Case Report
Article Title	Metastatic pancreatic cancer with activating BRAF V600E mutations: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Fang Li and Feng Shen
ORCID	Author(s) ORCID Number Fang Li http://orcid.org/0000-0002-2173-9635 Feng Shen http://orcid.org/0000-0001-9634-6265
Funding Agency and Grant Number
Corresponding Author	Feng Shen, Department of Medical Oncology, Zhongshan Hospital (Xiamen), Fudan University, No.668，Jinhu Road，Huli District, Xiamen 361015, Fujian Province, China. shen.feng@zs-hospital.sh.cn
Key Words	Pancreatic cancer; BRAF gene mutation; Targeted therapy; Prognosis; Case report
Core Tip	Pancreatic cancer (PC) is an extremely aggressive malignancy, characterized by a 5-year survival rate of merely 11% and is highly resistant to chemotherapy, radiotherapy and immunotherapy. PC is largely defined by core driver gene mutations. BRAF mutations are rare, but important because of the availability of targeted drugs. We report a rare case of PC with a high tumor burden with BRAF V600E mutation. Despite the use of chemotherapy and targeted therapy, the patient’s outcome remained poor. This case highlights the significance of molecular profiling in patients with pancreatic tumors, especially in young patients with aggressive characteristics.
Publish Date	2025-02-10 07:51
Citation	<p>Li F, Shen F. Metastatic pancreatic cancer with activating BRAF V600E mutations: A case report. <i>World J Clin Cases</i> 2025; 13(16): 101665</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i16/101665.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i16.101665

Full Article (PDF)	WJCC-13-101665-with-cover.pdf
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