Publication Name	World Journal of Clinical Oncology
Manuscript ID	101725
Country	China

Received	2024-09-25 03:35
Peer-Review Started	2024-09-26 03:36
To Make the First Decision
Return for Revision	2024-10-24 06:24
Revised	2024-11-04 15:55
Second Decision	2024-12-06 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-06 08:59
Articles in Press	2024-12-06 08:59
Publication Fee Transferred	2024-11-07 03:25
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-14 13:01
Publish the Manuscript Online	2025-01-21 09:22

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Basic Study
Article Title	Checkpoint kinase 1 in colorectal cancer: Upregulation of expression and promotion of cell proliferation
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Yan Pang, Zu-yuan Chen, Da-Tong Zeng, Dong-Ming Li, Qi Li, Wan-Ying Huang, Bin Li, Jia-Yuan Luo, Bang-Teng Chi, Qiu Huang, Zhen-Bo Feng and Rong-Quan He
ORCID	Author(s) ORCID Number Yu-Yan Pang http://orcid.org/0000-0002-3309-2517 Zu-yuan Chen http://orcid.org/0000-0001-9467-2200 Da-Tong Zeng http://orcid.org/0000-0002-3338-4122 Dong-Ming Li http://orcid.org/0009-0007-6671-2077 Qi Li http://orcid.org/0009-0003-4514-020X Wan-Ying Huang http://orcid.org/0000-0002-8314-5963 Bin Li http://orcid.org/0009-0002-9889-1800 Jia-Yuan Luo http://orcid.org/0000-0003-4712-5217 Bang-Teng Chi http://orcid.org/0009-0000-5504-5589 Qiu Huang http://orcid.org/0009-0004-9782-8097 Zhen-Bo Feng http://orcid.org/0000-0001-6361-4198 Rong-Quan He http://orcid.org/0000-0002-7752-2080
Funding Agency and Grant Number	Funding Agency Grant Number Innovation Project of Guangxi Graduate Education YCBZ2023096 Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project Z20210442 China Undergraduate Innovation and Entrepreneurship Training Program S202410598185 Future Academic Star of Guangxi Medical University WLXSZX24101
Corresponding Author	Zhen-Bo Feng, PhD, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Shuangyong Road 6, Nanning 530021, Guangxi Zhuang Autonomous Region, China. fengzhenbo_gxmu@163.com
Key Words	Colorectal cancer; Checkpoint kinase 1; Single-cell sequencing; Immunohistochemistry; Molecular docking
Core Tip	This study demonstrates that checkpoint kinase 1 (CHEK1) is comparatively overexpressed in colorectal cancer (CRC) and is closely associated with tumor proliferation. Based on single-cell RNA sequencing and immunohistochemistry, the findings highlight CHEK1’s potential as a novel biomarker and therapeutic target in CRC. Furthermore, the research uncovers nitidine chloride as a specific CHEK1 inhibitor, suggesting promising avenues for targeted therapies to improve patient outcomes. These insights underscore the clinical relevance of CHEK1 in CRC management and the need for further exploration of its mechanistic roles.
Publish Date	2025-01-21 09:22
Citation	<p>Pang YY, Chen ZY, Zeng DT, Li DM, Li Q, Huang WY, Li B, Luo JY, Chi BT, Huang Q, Feng ZB, He RQ. Checkpoint kinase 1 in colorectal cancer: Upregulation of expression and promotion of cell proliferation. <i>World J Clin Oncol</i> 2025; 16(3): 101725</p>
URL	https://www.wjgnet.com/2218-4333/full/v16/i3/101725.htm
DOI	https://dx.doi.org/10.5306/wjco.v16.i3.101725

Full Article (PDF)	WJCO-16-101725-with-cover.pdf
Manuscript File	101725_Auto_Edited_015203.docx
Answering Reviewers	101725-answering-reviewers.pdf
Audio Core Tip	101725-audio.mp3
Biostatistics Review Certificate	101725-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	101725-conflict-of-interest-statement.pdf
Copyright License Agreement	101725-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101725-foundation-statement.pdf
Institutional Review Board Approval Form or Document	101725-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	101725-non-native-speakers.pdf
Supplementary Material	101725-supplementary-material.pdf
Peer-review Report	101725-peer-reviews.pdf
Scientific Misconduct Check	101725-scientific-misconduct-check.png
Scientific Editor Work List	101725-scientific-editor-work-list.pdf
CrossCheck Report	101725-crosscheck-report.pdf