| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Epidemiology, treatment patterns, and associated risk factors in perianal fistulizing Crohn’s disease: A systematic literature review
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Caroline McKay, Anna Bolzani, Scarlette Kienzle, Parnia Geransar and Julian Panés |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Takeda Pharmaceuticals USA, Inc. Medical writing support was provided by Luke Humphreys, PhD, of Oxford PharmaGenesis, Oxford, UK and was funded by Takeda Development Center Americas, Inc |
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| Corresponding Author |
Julian Panés, MD, Professor, Department of Gastroenterology, Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Carrer de Villarroel, 170, L'Eixample, Barcelona 08036, Spain. julian.panes@gmail.com |
| Key Words |
Complex perianal fistula; Crohn’s disease; Epidemiology; Treatment patterns; Morbidity; Risk factors |
| Core Tip |
This systematic literature review summarizes data from recent studies reporting the epidemiology of Crohn’s perianal fistulas (CPF), treatment patterns, therapeutic response, morbidity, and mortality, alongside risk/protective factors associated with CPF development, treatment failure, and reasons for undergoing multiple CPF-related surgeries. Substantial variability in outcomes was observed, indicating the need for standardized CPF study designs and consistent definitions for CPF and CPF-related clinical outcomes to achieve optimal treatment strategies and improved patient outcomes. |
| Publish Date |
2025-07-23 11:10 |
| Citation |
<p>McKay C, Bolzani A, Kienzle S, Geransar P, Panés J. Epidemiology, treatment patterns, and associated risk factors in perianal fistulizing Crohn’s disease: A systematic literature review. <i>World J Gastrointest Surg</i> 2025; 17(7): 101767</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i7/101767.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i7.101767 |
