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Articles Published Processes
12/26/2024 3:04:22 AM | Browse: 34 | Download: 91
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Received |
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2024-09-25 16:27 |
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Peer-Review Started |
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2024-09-25 16:27 |
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To Make the First Decision |
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Return for Revision |
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2024-10-25 07:43 |
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Revised |
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2024-10-25 19:52 |
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Second Decision |
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2024-11-07 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-11-07 08:50 |
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Articles in Press |
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2024-11-07 08:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-11-19 03:36 |
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Publish the Manuscript Online |
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2024-12-26 03:04 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Bile acid therapy for primary biliary cholangitis: Pathogenetic validation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vasiliy I Reshetnyak and Igor V Maev |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vasiliy I Reshetnyak, MD, PhD, Department of Propaedeutics of Internal Diseases and Gastroenterology, Russian University of Medicine, No. 20 Delegatskaya Street, Build 1, Moscow 127473, Russia. vasiliy.reshetnyak@yandex.ru |
| Key Words |
Primary biliary cholangitis; Treatment of primary biliary cholangitis with bile acids; Ursodeoxycholic acid; Obeticholic acid; Tauroursodeoxycholic acid; Norursodeoxycholic acid |
| Core Tip |
The review is devoted to the issues of treatment of primary biliary cholangitis (PBC) with bile acid preparations. The mechanisms of beneficial action of ursodeoxycholic acid and its derivatives (tauroursodeoxycholic acid, obeticholic acid, norursodeoxycholic acid) are considered taking into account the pathogenetic mechanisms of PBC development known so far. The assumptions about the development of new therapeutic approaches in the treatment of PBC taking into account the discovery of the disruption of the mechanisms of bicarbonate formation by cholangiocytes in PBC were outlined. This may serve as a basis for the development of new targeting drugs aimed at local reduction of microRNA 506 activity or activation of anion exchanger 2 in cholangiocytes. |
| Publish Date |
2024-12-26 03:04 |
| Citation |
<p>Reshetnyak VI, Maev IV. Bile acid therapy for primary biliary cholangitis: Pathogenetic validation. <i>World J Exp Med</i> 2025; 15(1): 101771</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i1/101771.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i1.101771 |
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