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Articles Published Processes
12/30/2024 9:47:24 AM | Browse: 38 | Download: 170
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Received |
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2024-09-26 16:59 |
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Peer-Review Started |
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2024-10-01 05:36 |
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To Make the First Decision |
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Return for Revision |
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2024-11-06 08:39 |
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Revised |
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2024-11-15 07:29 |
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Second Decision |
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2024-11-26 11:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-12-05 07:16 |
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Articles in Press |
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2024-12-05 07:16 |
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Publication Fee Transferred |
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2024-11-18 05:29 |
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Edit the Manuscript by Language Editor |
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2024-12-06 13:49 |
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Typeset the Manuscript |
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2024-12-11 02:46 |
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Publish the Manuscript Online |
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2024-12-30 09:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui Liu, Ting Li, Xin-Lei Chen, Hong-Ling Yu and Ye-Rong Yu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ye-Rong Yu, MD, Professor, Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. yerongyu@scu.edu.cn |
| Key Words |
Euglycemic clamp; Target glucose setting; Healthy subject; C-peptide; Pharmacodynamics; Endogenous insulin secretion |
| Core Tip |
Insulin therapy is of great importance in anti-diabetes treatment. This study focuses on the preclinical assessment of insulin preparation using the euglycemic clamp technique in healthy subjects. Typically, blood glucose is usually maintained below the individual’s baseline throughout the clamp to inhibit endogenous insulin secretion. The hypoglycemic risk would increase if the BG baseline is relatively lower. This retrospective cohort study enrolled euglycemic clamps evaluating the pharmacokinetics and pharmacodynamics of insulin aspart to explore optimal methodologies for conducting euglycemic clamps under these circumstances. |
| Publish Date |
2024-12-30 09:47 |
| Citation |
<p>Liu H, Li T, Chen XL, Yu HL, Yu YR. Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations. <i>World J Diabetes</i> 2025; 16(2): 101779</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i2/101779.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i2.101779 |
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