Publication Name	World Journal of Hepatology
Manuscript ID	101798
Country	China

Received	2024-09-27 02:53
Peer-Review Started	2024-10-01 05:37
To Make the First Decision
Return for Revision	2024-11-01 10:02
Revised	2024-11-13 15:11
Second Decision	2024-11-22 03:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-22 13:30
Articles in Press	2024-11-22 13:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-29 04:42
Publish the Manuscript Online	2025-01-06 08:47

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Potential mechanisms and therapeutic prospects of the association between Helicobacter pylori infection and metabolic dysfunction-associated steatohepatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Guo-E Gou, Ting Li, Chen-Rui Liu, Ting Meng and Ya-Ping Li
ORCID	Author(s) ORCID Number Ya-Ping Li http://orcid.org/0000-0002-0900-5559
Funding Agency and Grant Number	Funding Agency Grant Number Basic and Clinical Integration Project of Xi’an Jiaotong University YXJLRH2022067
Corresponding Author	Ya-Ping Li, MD, PhD, Department of Infectious Diseases, Xi'an Jiaotong University Second Affiliated Hospital, No. 157 West 5th Road, Xincheng District, Xi'an 710004, Shaanxi Province, China. liyaping8605@xjtu.edu.cn
Key Words	Helicobacter pylori; Metabolic dysfunction-associated steatohepatitis; Gut-liver axis; Insulin resistance
Core Tip	The association between Helicobacter pylori (H. pylori) infection and metabolic dysfunction-associated steatohepatitis (MASH) has been confirmed in large-scale multicenter studies, suggesting that H. pylori is an independent risk factor for MASH development. This study revealed that H. pylori may influence MASH through chronic inflammation, insulin resistance, and the gut-liver axis, providing new insights into the pathogenesis of metabolic liver diseases. On the basis of these findings, H. pylori eradication therapy may offer a novel strategy for the prevention and treatment of MASH. Future research should focus on the molecular mechanisms linking H. pylori infection and MASH, particularly genetic susceptibility, gene polymorphisms, and metabolic pathways, in the treatment of MASH.
Publish Date	2025-01-06 08:47
Citation	<p>Gou GE, Li T, Liu CR, Meng T, Li YP. Potential mechanisms and therapeutic prospects of the association between Helicobacter pylori infection and metabolic dysfunction-associated steatohepatitis. <i>World J Hepatol</i> 2025; 17(1): 101798</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i1/101798.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i1.101798

Full Article (PDF)	WJH-17-101798-with-cover.pdf
Manuscript File	101798_Auto_Edited_103645.docx
Answering Reviewers	101798-answering-reviewers.pdf
Audio Core Tip	101798-audio.wav
Conflict-of-Interest Disclosure Form	101798-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	101798-non-native-speakers.pdf
Peer-review Report	101798-peer-reviews.pdf
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Scientific Editor Work List	101798-scientific-editor-work-list.pdf
CrossCheck Report	101798-crosscheck-report.pdf