| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Basic Study |
| Article Title |
Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Hai Chen, Bo Lan, Ying-Ying Zhang, Guo-Hui Li, Yu-Long Qian, Ming-Xing Hu, Yin-Lin Tian, Wei-Dong Zang, Jing Cao, Guang-Hai Wang and Yi-Gang Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Xiaogan, China |
XGKJ2023010036 |
|
| Corresponding Author |
Yi-Gang Wang, Associate Chief Physician, Department of Psychiatry, Xiaogan Rehabilitation Hospital, No. 99 Huanchuan Road, Xiaonan District, Xiaogan 432000, Hubei Province, China. wygang1004@163.com |
| Key Words |
Zona incerta; Gamma-aminobutyric acid-ergic; Depression; Anxiety; Animal behavior studies; Whole-cell patch-clamp |
| Core Tip |
Gamma-aminobutyric acid (GABA)-ergic dysfunction may play a role in the onset of depression. Case reports have indicated that deep brain stimulation of the zona incerta (ZI), which is abundant in GABAergic neurons, can modify depressive and anxiety symptoms. However, direct evidence linking ZI GABAergic neurons to depression-related behaviors in rodents is limited. This study demonstrated chronic resistant stress induced depression-like and anxiety-like behaviors in mice and reduced neuronal excitability. Chemogenetic activation alleviated these symptoms, whereas inhibition altered the behavior of normal mice. These findings suggested that ZI GABAergic neurons may serve as potential therapeutic targets for depression. |
| Publish Date |
2025-01-14 08:49 |
| Citation |
<p>Chen SH, Lan B, Zhang YY, Li GH, Qian YL, Hu MX, Tian YL, Zang WD, Cao J, Wang GH, Wang YG. Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress. <i>World J Psychiatry</i> 2025; 15(2): 101807</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i2/101807.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i2.101807 |
