Publication Name	World Journal of Psychiatry
Manuscript ID	101818
Country	China

Received	2024-09-28 07:22
Peer-Review Started	2024-09-28 07:22
To Make the First Decision
Return for Revision	2024-10-23 10:59
Revised	2024-11-04 04:47
Second Decision	2024-12-17 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-17 08:45
Articles in Press	2024-12-17 08:45
Publication Fee Transferred	2024-11-15 06:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-30 04:35
Publish the Manuscript Online	2025-01-14 08:49

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Case Control Study
Article Title	Immune indicators and depression in adolescents: Associations with monocytes, lymphocytes, and direct bilirubin
Manuscript Source	Unsolicited Manuscript
All Author List	Jian Dai, Xiao-Tong Lin, Lu-Lu Shen, Xi-Wen Zhang, Zi-Wen Ding, Jing Wang, Xi-Wang Fan and Wei-Dong Ning
ORCID	Author(s) ORCID Number Xi-Wang Fan http://orcid.org/0000-0003-4180-0496 Wei-Dong Ning http://orcid.org/0009-0002-4212-2228
Funding Agency and Grant Number	Funding Agency Grant Number the Medical Discipline Construction Project of Pudong Health Committee of Shanghai PWZzb2022-09 Nanning City Science Research and Technology Development Program ZC20233017 Guangxi Medical and Health Appropriate Technology Development and Promotion Project S2021061
Corresponding Author	Wei-Dong Ning, The Department of Psychological Health, The 980th Hospital of Joint Support Force of China People's Liberation Army, Qiaoxi District, Shijiazhuang 050051, Hebei Province, China. ningweidong256@163.com
Key Words	Depression; Adolescents; Immune markers; Monocyte; Lymphocyte; Direct bilirubin
Core Tip	This study investigated the relationship between immune markers, specifically monocyte and lymphocyte counts and direct bilirubin levels, and depression in adolescents. By comparing 145 adolescents with depression with 163 healthy controls, we found significantly elevated levels of immune markers in patients with depression, particularly in severe cases. These findings suggest that elevated direct bilirubin levels may serve as potential immune markers for detecting depression, highlighting the importance of immune responses in understanding the mental health of adolescents.
Publish Date	2025-01-14 08:49
Citation	<p>Dai J, Lin XT, Shen LL, Zhang XW, Ding ZW, Wang J, Fan XW, Ning WD. Immune indicators and depression in adolescents: Associations with monocytes, lymphocytes, and direct bilirubin. <i>World J Psychiatry</i> 2025; 15(2): 101818</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i2/101818.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i2.101818

Full Article (PDF)	WJP-15-101818-with-cover.pdf
STROBE Statement	101818-STROBE-statement.pdf
Manuscript File	101818_Auto_Edited_082845.docx
Answering Reviewers	101818-answering-reviewers.pdf
Audio Core Tip	101818-audio.mp3
Biostatistics Review Certificate	101818-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	101818-conflict-of-interest-statement.pdf
Copyright License Agreement	101818-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101818-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	101818-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	101818-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	101818-non-native-speakers.pdf
Peer-review Report	101818-peer-reviews.pdf
Scientific Misconduct Check	101818-scientific-misconduct-check.jpg
Scientific Editor Work List	101818-scientific-editor-work-list.pdf
CrossCheck Report	101818-crosscheck-report.png
CrossCheck Report	101818-crosscheck-report.pdf