Publication Name	World Journal of Psychiatry
Manuscript ID	101906
Country	South Korea

Received	2024-09-30 09:57
Peer-Review Started	2024-09-30 09:57
To Make the First Decision
Return for Revision	2024-10-30 09:42
Revised	2024-11-12 06:07
Second Decision	2025-04-10 03:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-10 08:39
Articles in Press	2025-04-10 08:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-21 03:08
Publish the Manuscript Online	2025-07-10 03:52

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Letter to the Editor
Article Title	Optimizing perimenopausal mental health by integrating precision biomarkers, digital health interventions, and psychosocial care
Manuscript Source	Invited Manuscript
All Author List	Uchenna E Okpete and Haewon Byeon
ORCID	Author(s) ORCID Number Uchenna E Okpete http://orcid.org/0000-0003-3803-4583 Haewon Byeon http://orcid.org/0000-0002-3363-390X
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education No. RS-2023-00237287
Corresponding Author	Haewon Byeon, Associate Professor, PhD, Worker’s Care and Digital Health Lab, Department of Future Technology, Korea University of Technology and Education, Director 1600, Chungjeol-ro, Cheonan 31253, South Korea. bhwpuma@naver.com
Key Words	Perimenopause; Mental health; Anxiety; Depression; Hormone replacement therapy; Cognitive-behavioral therapy; Personalized care; Pharmacogenomics; Digital health
Core Tip	This article highlights the critical need for an integrated, personalized approach to perimenopausal mental health, addressing biological and psychosocial factors. Hormonal fluctuations, genetic predispositions, and lifestyle factors significantly shape mental health outcomes, while traditional treatments like selective serotonin reuptake inhibitors and hormone replacement therapy have limitations. Advancements in pharmacogenomics, metabolomics, and digital health technologies offer promising, individualized solutions. Integrative models combining hormone therapy, cognitive behavioral therapy, and lifestyle interventions show strong efficacy. However, healthcare accessibility and stigma remain challenges. Future efforts should focus on clinical validation, ethical implementation, and equitable care to optimize mental health outcomes and overall well-being for perimenopausal women.
Publish Date	2025-07-10 03:52
Citation	<p>Okpete UE, Byeon H. Optimizing perimenopausal mental health by integrating precision biomarkers, digital health interventions, and psychosocial care. <i>World J Psychiatry</i> 2025; 15(7): 101906</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i7/101906.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i7.101906

Full Article (PDF)	WJP-15-101906-with-cover.pdf
Manuscript File	101906_Auto_Edited_042048.docx
Answering Reviewers	101906-answering-reviewers.pdf
Audio Core Tip	101906-audio.mp3
Conflict-of-Interest Disclosure Form	101906-conflict-of-interest-statement.pdf
Copyright License Agreement	101906-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101906-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	101906-non-native-speakers.pdf
Peer-review Report	101906-peer-reviews.pdf
Scientific Misconduct Check	101906-scientific-misconduct-check.png
Scientific Editor Work List	101906-scientific-editor-work-list.pdf
CrossCheck Report	101906-crosscheck-report.pdf