| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Overexpression and clinicopathological significance of zinc finger protein 71 in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kai Qin, Dan-Dan Xiong, Zhen Qin, Ming-Jie Li, Qi Li, Zhi-Guang Huang, Yu-Xing Tang, Jian-Di Li, Yan-Ting Zhan, Rong-Quan He, Jie Luo, Hai-Quan Wang, Shu-Qi Zhang, Gang Chen, Dan-Ming Wei and Yi-Wu Dang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Joint Project on Regional High Incidence Diseases Research of Guangxi Natural Science Foundation |
2024GXNSFAA010057 and 2024GXNSFAA010085 |
| Natural Science Foundation of Guangxi, China |
2022GXNSFBA035657 |
| Guangxi Zhuang Autonomous Region Health Commission Self-Financed Scientific Research Project |
Z20210764 |
| Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project |
GXZYA20230270 and GXZYA20240305 |
| Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University (2022) |
|
|
| Corresponding Author |
Yi-Wu Dang, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. dangyiwu@gxmu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Zinc finger protein 71; Immunohistochemistry; Enrichment analysis; Immune infiltration |
| Core Tip |
This study identifies zinc finger protein 71 as a key marker significantly upregulated in hepatocellular carcinoma, linking its elevated levels to increased disease severity. Employing a comprehensive methodology, including immunohistochemistry, high-throughput analysis, and single-cell sequencing, we demonstrate the involvement of zinc finger protein 71 in promoting hepatocellular carcinoma progression through cell cycle and metabolic pathways. Our findings underscore its potential as a therapeutic target, especially given its association with immune cell infiltration, highlighting its role in the tumor microenvironment. |
| Publish Date |
2025-02-20 08:40 |
| Citation |
<p>Qin K, Xiong DD, Qin Z, Li MJ, Li Q, Huang ZG, Tang YX, Li JD, Zhan YT, He RQ, Luo J, Wang HQ, Zhang SQ, Chen G, Wei DM, Dang YW. Overexpression and clinicopathological significance of zinc finger protein 71 in hepatocellular carcinoma. <i>World J Hepatol</i> 2025; 17(2): 101914</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i2/101914.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i2.101914 |
