| ISSN |
1948-9358 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wu-Han Wei, Yuan-Ling Bai, Dong Zhu, Jing-Yu Zhang, Qi-Chuan Yin, Qiang Li, Cai-Qi Shen and Pei-Sheng Jin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| General Project of Xuzhou Science and Technology Bureau |
KC22070 |
|
| Corresponding Author |
Pei-Sheng Jin, MD, Professor, Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University, No. 84 Huaihai West Road, Quanshan District, Xuzhou 221006, Jiangsu Province, China. peishengjin@xzhmu.edu.cn |
| Key Words |
Apoptosis; Angiogenesis; Network pharmacology; Diabetic foot ulcer; Dl-3-n-butylphthalide |
| Core Tip |
Network pharmacology analysis demonstrated that Dl-3-n-butylphthalide (NBP) could treat diabetic foot ulcers (DFU) by modulating apoptosis and vascular signaling pathways. Moreover, improved neovascularization in DFU mice and enhanced the migration and proliferation of human umbilical vein endothelial cells and human dermal fibroblasts, while inhibiting apoptosis of human umbilical vein endothelial cells, human dermal fibroblasts, and human keratinocytes cells. The effects of NBP were mediated by activation of the advanced glycation end products-receptor of advanced glycation end products signaling pathway and binding to heme oxygenase 1, caspase 3, B cell leukemia/lymphoma 2, brain derived neurotrophic factor, and nuclear factor erythroid 2 L2, suggesting that NBP can potentially treat DFU by reducing apoptosis and promoting angiogenesis. |
| Publish Date |
2025-02-28 10:46 |
| Citation |
Wei WH, Bai YL, Zhu D, Zhang JY, Yin QC, Li Q, Shen CQ, Jin PS. Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis. World J Diabetes 2025; 16(4): 101916 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i4/101916.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i4.101916 |
