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Articles Published Processes
11/19/2025 5:57:28 AM | Browse: 68 | Download: 187
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Received |
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2024-10-01 04:52 |
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Peer-Review Started |
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2024-10-01 04:52 |
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First Decision by Editorial Office Director |
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2025-02-07 13:51 |
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Return for Revision |
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2025-02-07 13:51 |
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Revised |
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2025-02-28 12:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-04-07 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-04-07 08:42 |
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Articles in Press |
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2025-04-07 08:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-30 12:55 |
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Publish the Manuscript Online |
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2025-11-19 05:57 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Review |
| Article Title |
Towards curing type 1 diabetes: Prospects and challenges of allogeneic or xenogeneic donor islet cell transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Helen Jiang, David Henley and Fang-Xu Jiang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fang-Xu Jiang, Adjunct Associate Professor, PhD, School of Biomedical Sciences, University of Western Australia, 35 Stirling Hwy, Crawley, Perth 6009, Western Australia, Australia. fang-xu.jiang@perkins.uwa.edu.au |
| Key Words |
Type 1 diabetes mellitus; Human pluripotent stem cells; Islet transplantation; Insulin-secreting β-cells; Xenogeneic; Porcine islets; β-cell replacement therapy; Regenerative medicine; Insulin dependent diabetes mellitus; Pancreatic β-cells |
| Core Tip |
Type 1 diabetes is a lifelong disease that is debilitating and life-threatening due to severe hypoglycaemic events or impaired hypoglycaemic awareness. β-cell replacement with either pancreas or islet allotransplantation can reverse diabetes leading to improved quality of life. The limited supply of cadaveric organ donors is a major barrier to this therapeutic option. Thus, alternative sources of islets are being explored, mainly human pluripotent stem-cell derived islets and xenogeneic porcine islets. This review will concentrate on pre-clinical and clinical studies, in addition to the latest scientific discoveries relevant to type 1 diabetes transplantation therapy using allogeneic or xenogeneic donor islet cells. |
| Publish Date |
2025-11-19 05:57 |
| Citation |
Jiang H, Henley D, Jiang FX. Towards curing type 1 diabetes: Prospects and challenges of allogeneic or xenogeneic donor islet cell transplantation. World J Transplant 2025; 15(4): 101926 |
| URL |
https://www.wjgnet.com/2220-3230/full/v15/i4/101926.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v15.i4.101926 |
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