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Articles Published Processes
7/24/2025 9:11:34 AM | Browse: 78 | Download: 415
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Received |
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2025-02-12 08:10 |
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Peer-Review Started |
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2025-02-12 08:10 |
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First Decision by Editorial Office Director |
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2025-02-26 05:00 |
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Return for Revision |
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2025-02-26 05:00 |
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Revised |
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2025-03-07 16:43 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-06-09 09:47 |
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Second Decision by Editor-in-Chief |
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2025-06-14 06:43 |
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Final Decision by Editorial Office Director |
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2025-06-25 08:06 |
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Articles in Press |
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2025-06-25 08:06 |
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Edit the Manuscript by Language Editor |
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2025-06-29 08:02 |
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Typeset the Manuscript |
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2025-07-16 06:28 |
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Publish the Manuscript Online |
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2025-07-24 09:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
X inactive-specific transcript regulates mitochondrial function and neuronal differentiation of stem cells via IGF2BP2/CPT1A axis in models of spinal cord injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Xiang Zeng, Jin-Tao Ye, Si-Hua Huang and Ruo-Xi Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Si-Hua Huang, Associate Chief Physician, MD, Department of Orthopaedic Surgery, Second Affiliated Hospital of Medical School of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an 710004, Shaanxi Province, China. mbyp180@163.com |
| Key Words |
Spinal cord injury; Neural stem cell; X inactive-specific transcript; Mitochondrial function; Neuronal differentiation |
| Core Tip |
This study highlights the critical role of long non-coding RNA X inactive-specific transcript (XIST) in enhancing neural stem cell function for spinal cord injury (SCI) treatment. XIST significantly improves motor recovery and reduces inflammation in mouse models of SCI by promoting mitochondrial function and neuronal differentiation. These findings suggest that XIST regulates carnitine palmitoyl transferase 1A expression via the insulin-like growth factor 2 mRNA binding protein 2 pathway, providing a promising therapeutic target for the development of effective interventions against irreversible neurological deficits in SCI. Further exploration of the long-term effects of XIST may advance its clinical applications. |
| Publish Date |
2025-07-24 09:11 |
| Citation |
Zeng SX, Ye JT, Huang SH, Liu RX. X inactive-specific transcript regulates mitochondrial function and neuronal differentiation of stem cells via IGF2BP2/CPT1A axis in models of spinal cord injury. World J Stem Cells 2025; 17(7): 101929 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i7/101929.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i7.101929 |
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