| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Observational Study |
| Article Title |
Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui Wang, Yu-Xian Xu, Feng Xu, Chun-Hua Wang, Li-Hua Zhao, Li-Hua Wang, Wei-Guan Chen, Xue-Qin Wang, Cheng-Wei Duan and Jian-Bin Su |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
32101027 |
| Social Development Projects of Nantong |
MS12019019, HS2022004, and MS2023083 |
| Medical Research Project of the Jiangsu Health Commission |
Z2022058 |
|
| Corresponding Author |
Jian-Bin Su, Assistant Professor, MD, Department of Endocrinology, The Affiliated Hospital 2 of Nantong University, Nantong First People's Hospital, No. 666 Shengli Road, Nantong 226001, Jiangsu Province, China. sujbzjx@163.com |
| Key Words |
Blood urea nitrogen; Metabolic disturbance; Peripheral nerve function; Electromyography; Type 2 diabetes |
| Core Tip |
Blood urea nitrogen (BUN) is a well-established biomarker utilized in clinical diagnostic evaluations. When renal function is relatively normal, an increase in BUN may indicate a negative nitrogen balance, underlying metabolic disorders, and potential adverse outcomes. In the present study, our findings indicate that increased BUN levels are independently associated with compromised peripheral nerve function in patients with type 2 diabetes (T2D) and may serve as a potential risk factor for peripheral nerve dysfunction in these patients. Future interventions to lower BUN levels by improving nutritional status and balancing protein metabolism may alleviate peripheral nerve dysfunction in patients with T2D. |
| Publish Date |
2025-02-28 10:46 |
| Citation |
<p>Wang R, Xu YX, Xu F, Wang CH, Zhao LH, Wang LH, Chen WG, Wang XQ, Duan CW, Su JB. Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes. <i>World J Diabetes</i> 2025; 16(4): 101966</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i4/101966.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i4.101966 |
