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Articles Published Processes
11/29/2024 8:40:09 AM | Browse: 51 | Download: 167
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Received |
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2024-10-03 09:55 |
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Peer-Review Started |
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2024-10-03 09:55 |
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To Make the First Decision |
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Return for Revision |
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2024-10-25 03:59 |
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Revised |
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2024-10-25 09:35 |
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Second Decision |
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2024-11-13 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-11-13 06:26 |
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Articles in Press |
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2024-11-13 06:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-11-14 07:16 |
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Publish the Manuscript Online |
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2024-11-29 08:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Calculus bovis hijacks the tumor microenvironment in liver cancer cells in a multifaceted approach: A falling row of dominoes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Said G Farhat and Karam Karam |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Said G Farhat, MD, Department of Internal Medicine, Division of Gastroenterology, Saint Georges Hospital University Medical Center, Rmeil Street, Ashrafieh, Beirut 3187, Beyrouth, Lebanon. saidfarhat@hotmail.com |
| Key Words |
Calculus bovis; Wnt/β-catenin signaling pathway; M2-tumor-associated macrophages; Liver cancer; Transforming growth factor-β; Angiogenesis; Liver fibrosis |
| Core Tip |
Calculus bovis (C. bovis) is an herb used in traditional Chinese medicine known for its various anti-inflammatory and anti-tumorigenic effects. C. bovis influences the tumor microenvironment by targeting immune-related pathways. Transcriptome sequencing revealed that C. bovis plays a crucial role in the regulation of M2-tumor-associated macrophages polarization and halting the Wnt/β-catenin pathway. This study provides a solid and promising evidence concerning potential drug therapy in the treatment of liver cancer. In this paper, we shed light on the inevitable “cross talk” between the Wnt and transforming growth factor-β signaling pathways, thus connecting angiogenesis, oncogenesis and liver fibrosis. C. bovis is deemed a priming molecule that sets the stage for a series of related and inter-connected events, such as angiogenesis, hepatocarcinogenesis and hepatic fibrosis. This process brings about the “domino effect” whereby one event uncovers another related event as a falling row of dominoes. |
| Publish Date |
2024-11-29 08:40 |
| Citation |
<p>Farhat SG, Karam K. Calculus bovis hijacks the tumor microenvironment in liver cancer cells in a multifaceted approach: A falling row of dominoes. <i>World J Gastroenterol</i> 2024; 30(48): 5221-5224</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i48/5221.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i48.5221 |
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