Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	101991
Country	China

Received	2024-10-04 07:12
Peer-Review Started	2024-10-04 07:12
To Make the First Decision
Return for Revision	2024-11-10 08:16
Revised	2024-11-21 07:44
Second Decision	2025-01-08 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-08 07:55
Articles in Press	2025-01-08 07:55
Publication Fee Transferred	2024-12-16 03:49
Edit the Manuscript by Language Editor	2025-01-14 02:29
Typeset the Manuscript	2025-01-21 02:45
Publish the Manuscript Online	2025-02-14 10:33

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Basic Study
Article Title	Irreversible electroporation combined with anti-programmed cell death protein 1 therapy promotes tumor antigen-specific CD8+ T cells response
Manuscript Source	Unsolicited Manuscript
All Author List	Yang-Yang Ma, Xiao-Hua Wang, Jian-Ying Zeng, Ji-Bing Chen and Li-Zhi Niu
ORCID	Author(s) ORCID Number Yang-Yang Ma http://orcid.org/0000-0003-0092-963X Li-Zhi Niu http://orcid.org/0000-0002-8808-0978
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Program of Guangzhou 202102010077 International Science Foundation of Guangzhou Fuda Cancer Hospital Y2020-ZD-03
Corresponding Author	Li-Zhi Niu, Chief Physician, MD, PhD, Department of Oncology, Guangzhou Fuda Cancer Hospital, No. 2 Tangde West Road, Tianhe District, Guangzhou 510665, Guangdong Province, China. niuboshi@fudahospital.com
Key Words	Irreversible electroporation; Pancreatic cancer; Programmed cell death protein 1 blockade; CD8+ T cell; Anticancer immunity
Core Tip	This study highlights the synergistic effect of combining irreversible electroporation with anti-programmed cell death protein 1 therapy in the treatment of subcutaneous pancreatic cancer. The combination significantly enhances T lymphocyte infiltration, elevates key cytokine levels, and promotes CD8+ T cell-mediated immune responses, resulting in a marked reduction in tumor volume. These findings suggest a promising avenue for improving immunotherapy strategies in pancreatic cancer through enhanced local tumor ablation methods.
Publish Date	2025-02-14 10:33
Citation	<p>Ma YY, Wang XH, Zeng JY, Chen JB, Niu LZ. Irreversible electroporation combined with anti-programmed cell death protein 1 therapy promotes tumor antigen-specific CD8+ T cells response. <i>World J Gastrointest Oncol</i> 2025; 17(3): 101991</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i3/101991.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i3.101991

Full Article (PDF)	WJGO-17-101991-with-cover.pdf
The ARRIVE Guidelines	101991-The-ARRIVE-Guidelines.pdf
Manuscript File	101991_Auto_Edited_083734.docx
Answering Reviewers	101991-answering-reviewers.pdf
Audio Core Tip	101991-audio.mp3
Biostatistics Review Certificate	101991-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	101991-conflict-of-interest-statement.pdf
Copyright License Agreement	101991-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101991-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	101991-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	101991-non-native-speakers.pdf
Peer-review Report	101991-peer-reviews.pdf
Scientific Misconduct Check	101991-scientific-misconduct-check.png
Scientific Editor Work List	101991-scientific-editor-work-list.pdf
CrossCheck Report	101991-crosscheck-report.png
CrossCheck Report	101991-crosscheck-report.pdf