Publication Name	World Journal of Diabetes
Manuscript ID	101994
Country	China

Received	2024-10-14 05:44
Peer-Review Started	2024-10-16 00:48
To Make the First Decision
Return for Revision	2024-12-09 05:45
Revised	2025-01-04 15:25
Second Decision	2025-02-10 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-10 06:49
Articles in Press	2025-02-10 06:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-21 01:55
Publish the Manuscript Online	2025-02-28 10:47

ISSN	1948-9358 (online)
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Category	Cell Biology
Manuscript Type	Editorial
Article Title	Exploring a novel mechanism for targeting β-arrestin-2 in the management of diabetic nephropathy
Manuscript Source	Invited Manuscript
All Author List	Na Liu, Wei-Tao Yan and Kun Xiong
ORCID	Author(s) ORCID Number Kun Xiong http://orcid.org/0000-0002-3103-6028
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82303047, 82372507, 82172196 and 32401046 Natural Science Foundation of Hunan Province 2022JJ40801
Corresponding Author	Kun Xiong, PhD, Professor, Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, No. 172 Tongzipo Road, Changsha 410013, Hunan Province, China. xiongkun2001@163.com
Key Words	Diabetes mellitus; Diabetic nephropathy; β-arrestin-2; Endoplasmic reticulum stress; ATF6 signaling pathway
Core Tip	Diabetic nephropathy (DN), a complication of diabetes mellitus, poses significant challenges in the management. Liu et al observed that β-arrestin-2 deteriorates DN through inducing endoplasmic reticulum (ER) stress, and inhibiting β-arrestin-2 may protect glomerular endothelial cells and mitigate DN progression by curbing ER stress. This research underscores the significance of ER stress in DN and reveals an innovative molecular pathway involving β-arrestin-2 that may contribute to DN progression, offering potential targets for therapeutic interventions. Nevertheless, further clinical validation and investigation are necessary to confirm the clinical application of these findings.
Publish Date	2025-02-28 10:47
Citation	<p>Liu N, Yan WT, Xiong K. Exploring a novel mechanism for targeting β-arrestin-2 in the management of diabetic nephropathy. <i>World J Diabetes</i> 2025; 16(4): 101994</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i4/101994.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i4.101994

Full Article (PDF)	WJD-16-101994-with-cover.pdf
Manuscript File	101994_Auto_Edited_054902.docx
Answering Reviewers	101994-answering-reviewers.pdf
Audio Core Tip	101994-audio.mp3
Conflict-of-Interest Disclosure Form	101994-conflict-of-interest-statement.pdf
Copyright License Agreement	101994-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101994-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	101994-non-native-speakers.pdf
Peer-review Report	101994-peer-reviews.pdf
Scientific Misconduct Check	101994-scientific-misconduct-check.png
Scientific Editor Work List	101994-scientific-editor-work-list.pdf
CrossCheck Report	101994-crosscheck-report.pdf