Publication Name	World Journal of Gastroenterology
Manuscript ID	10201
Country	China

Received	2014-03-19 09:53
Peer-Review Started	2014-03-19 13:07
First Decision by Editorial Office Director
Return for Revision	2014-05-05 10:36
Revised	2014-05-16 10:03
Publication Fee Transferred
Second Decision by Editor	2014-07-16 12:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-16 13:06
Articles in Press	2014-07-16 17:56
Edit the Manuscript by Language Editor	2014-07-27 20:36
Typeset the Manuscript	2014-12-27 20:28
Publish the Manuscript Online	2015-01-18 16:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Autobiography
Article Title	E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Yuan Wei, Lin-Hai Yan, Xiao-Tong Wang, Lei Li, Wen-Long Cao, Xiao-Shi Zhang, Ze-Xu Zhan, Han Yu, Yu-Bo Xie and Qiang Xiao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30860273 National Natural Science Foundation of China 81060201 Natural Science Foundation of Guangxi 2011GXNSFA018273 Natural Science Foundation of Guangxi 2013GXNSFAA019163 Key Health Science Project of Guangxi Key1298003-2-6
Corresponding Author	Qiang Xiao, Professor, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. xiaoqiang20050@aliyun.com
Key Words	E2F-1; Gastric cancer; Lentiviral vector; Mouse model
Core Tip	Transcription factor E2F-1 is the prototypical E2F and is often implicated in DNA synthesis and repair, cell proliferation, and apoptosis. Our preliminary study revealed that high expression of E2F-1 significantly suppressed gastric cancer (GC) cell line progression in vitro. However, the role of E2F-1 overexpression in GC in vivo remains unknown. Our results showed that overexpression of E2F-1 significantly inhibited tumor growth and promoted tumor cell apoptosis in vivo. Survivin, Bcl-2, cyclin D1, S-phase kinase-associated protein 2 and c-Myc were upregulated, and Bax was downregulated by E2F-1. E2F-1 inhibits growth of GC cells via regulating multiple signaling pathways.
Publish Date	2015-01-18 16:09
Citation	Wei WY, Yan LH, Wang XT, Li L, Cao WL, Zhang XS, Zhan ZX, Yu H, Xie YB, Xiao Q. E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo. World J Gastroenterol 2015; 21(2): 491-501
URL	http://www.wjgnet.com/1007-9327/full/v21/i2/491.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i2.491

Full Article (PDF)	WJG-21-491.pdf
Full Article (Word)	WJG-21-491.doc
Manuscript File	10201-Review.doc
Answering Reviewers	10201-Answering reviewers.pdf
Copyright License Agreement	10201-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10201-Language certificate.pdf
Peer-review Report	10201-Peer review.pdf
Scientific Misconduct Check	10201-CrossCheck.jpg
Scientific Editor Work List	10201-Scientific editor work list.pdf