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Articles Published Processes
1/18/2015 4:09:00 PM | Browse: 1177 | Download: 1749
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Received |
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2014-03-19 09:53 |
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Peer-Review Started |
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2014-03-19 13:07 |
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To Make the First Decision |
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2014-04-28 13:57 |
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Return for Revision |
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2014-05-05 10:36 |
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Revised |
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2014-05-16 10:03 |
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Second Decision |
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2014-07-16 12:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-07-16 13:06 |
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Articles in Press |
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2014-07-16 17:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-07-27 20:36 |
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Typeset the Manuscript |
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2014-12-27 20:28 |
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Publish the Manuscript Online |
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2015-01-18 16:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Autobiography |
| Article Title |
E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Yuan Wei, Lin-Hai Yan, Xiao-Tong Wang, Lei Li, Wen-Long Cao, Xiao-Shi Zhang, Ze-Xu Zhan, Han Yu, Yu-Bo Xie and Qiang Xiao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30860273 |
| National Natural Science Foundation of China |
81060201 |
| Natural Science Foundation of Guangxi |
2011GXNSFA018273 |
| Natural Science Foundation of Guangxi |
2013GXNSFAA019163 |
| Key Health Science Project of Guangxi |
Key1298003-2-6 |
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| Corresponding Author |
Qiang Xiao, Professor, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. xiaoqiang20050@aliyun.com |
| Key Words |
E2F-1; Gastric cancer; Lentiviral vector; Mouse model |
| Core Tip |
Transcription factor E2F-1 is the prototypical E2F and is often implicated in DNA synthesis and repair, cell proliferation, and apoptosis. Our preliminary study revealed that high expression of E2F-1 significantly suppressed gastric cancer (GC) cell line progression in vitro. However, the role of E2F-1 overexpression in GC in vivo remains unknown. Our results showed that overexpression of E2F-1 significantly inhibited tumor growth and promoted tumor cell apoptosis in vivo. Survivin, Bcl-2, cyclin D1, S-phase kinase-associated protein 2 and c-Myc were upregulated, and Bax was downregulated by E2F-1. E2F-1 inhibits growth of GC cells via regulating multiple signaling pathways. |
| Publish Date |
2015-01-18 16:09 |
| Citation |
Wei WY, Yan LH, Wang XT, Li L, Cao WL, Zhang XS, Zhan ZX, Yu H, Xie YB, Xiao Q. E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo. World J Gastroenterol 2015; 21(2): 491-501 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i2/491.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i2.491 |
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