Publication Name	World Journal of Diabetes
Manuscript ID	102014
Country	China

Received	2024-10-07 02:33
Peer-Review Started	2024-10-10 01:49
To Make the First Decision
Return for Revision	2024-11-08 06:05
Revised	2024-11-21 04:18
Second Decision	2025-01-02 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-02 05:55
Articles in Press	2025-01-02 05:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-13 03:40
Publish the Manuscript Online	2025-01-21 09:26

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Letter to the Editor
Article Title	From metabolic regulation to kidney protection: β-arrestin 2 as a dual-function therapeutic target
Manuscript Source	Invited Manuscript
All Author List	Jian Yang, Cheng-Zhi Zhang and Jing Zhang
ORCID	Author(s) ORCID Number Jian Yang http://orcid.org/0000-0002-1391-1482 Jing Zhang http://orcid.org/0009-0000-1410-0641
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82471616, 82170418, 82271618 Natural Science Foundation of Hubei Province 2022CFA015 Central Guiding Local Science and Technology Development Project 2022BGE237 Key Research and Development Program of Hubei Province 2022BCE001, 2022DCC014, 2023BCB139 Hubei Provincial Health Commission Project WJ2023M151
Corresponding Author	Jing Zhang, MD, Central Laboratory, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, No. 183 Yiling Avenue, Yichang 443003, Hubei Province, China. zhangjing@ctgu.edu.cn
Key Words	Type 2 diabetes; Diabetic nephropathy; Βeta-arrestin 2; Βeta-arrestin 1; Metabolic regulation; Tissue-specific signaling; Therapeutic strategies; Multi-target therapies
Core Tip	This article highlights the dual-function potential of β-arrestin 2 as a therapeutic target for both diabetic nephropathy and metabolic regulation. Recent findings by Liu et al demonstrated that β-arrestin 2 exacerbates kidney damage in diabetic nephropathy by promoting glomerular endothelial cell apoptosis via the endoplasmic reticulum stress pathway. Conversely, β-arrestin 2 plays a significant role in regulating metabolic processes, such as hepatic glucose production, insulin secretion, and adipose tissue function. Its tissue-specific effects make β-arrestin 2 a promising target for therapeutic strategies, with ongoing advancements in biased ligands, small molecule modulators, and RNA aptamers.
Publish Date	2025-01-21 09:26
Citation	<p>Yang J, Zhang CZ, Zhang J. From metabolic regulation to kidney protection: β-arrestin 2 as a dual-function therapeutic target. <i>World J Diabetes</i> 2025; 16(3): 102014</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i3/102014.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i3.102014

Full Article (PDF)	WJD-16-102014-with-cover.pdf
Manuscript File	102014_Auto_Edited_080643.docx
Answering Reviewers	102014-answering-reviewers.pdf
Audio Core Tip	102014-audio.mp3
Conflict-of-Interest Disclosure Form	102014-conflict-of-interest-statement.pdf
Copyright License Agreement	102014-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102014-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	102014-non-native-speakers.pdf
Peer-review Report	102014-peer-reviews.pdf
Scientific Misconduct Check	102014-scientific-misconduct-check.png
Scientific Editor Work List	102014-scientific-editor-work-list.pdf
CrossCheck Report	102014-crosscheck-report.pdf