Publication Name	World Journal of Hepatology
Manuscript ID	102027
Country	Japan

Received	2024-10-06 11:13
Peer-Review Started	2024-10-06 11:13
To Make the First Decision
Return for Revision	2025-02-07 13:22
Revised	2025-02-21 11:56
Second Decision	2025-04-09 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-09 06:27
Articles in Press	2025-04-09 06:27
Publication Fee Transferred	2025-02-26 12:46
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-18 01:12
Publish the Manuscript Online	2025-04-25 08:23

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Quantification of Streptococcus salivarius using the digital polymerase chain reaction as a liver fibrosis marker
Manuscript Source	Unsolicited Manuscript
All Author List	Shuichiro Iwasaki, Akira Také, Haruki Uojima, Kazue Horio, Yoshihiko Sakaguchi, Kazuyoshi Gotoh, Takashi Satoh, Hisashi Hidaka, Yasuhito Tanaka, Shunji Hayashi and Chika Kusano
ORCID	Author(s) ORCID Number Shuichiro Iwasaki http://orcid.org/0000-0002-8252-2771 Haruki Uojima http://orcid.org/0000-0003-1719-1352 Takashi Satoh http://orcid.org/0000-0002-0728-3125 Hisashi Hidaka http://orcid.org/0000-0002-4151-5663 Yasuhito Tanaka http://orcid.org/0000-0002-2473-6966 Chika Kusano http://orcid.org/0000-0002-3789-4787
Funding Agency and Grant Number	Funding Agency Grant Number JSPS KAKENHI 23K15083
Corresponding Author	Haruki Uojima, MD, PhD, Doctor, Doctor, Department of Gastroenterology, Kitasato University School of Medicine, Minami-ku Kitasato1-15-1, Sagamihara 252-0373, Kanagawa, Japan. kiruha@kitasato-u.ac.jp
Key Words	Chronic liver disease; Streptococcus salivarius; Digital PCR; Liver fibrosis; Liver cirrhosis; Quantification
Core Tip	This is a retrospective single-centre observational study and the first to quantify Streptococcus salivarius (S. salivarius) load in stool samples as a liver fibrosis marker for patients with chronic liver disease (CLD) Using digital PCR (dPCR). DPCR is a high precision technique for measuring the absolute quantity of the bacterial species. The quantification of S. salivarius using dPCR is proposed as a potentially useful biomarker for liver fibrosis in patients with CLD.
Publish Date	2025-04-25 08:23
Citation	<p>Iwasaki S, Také A, Uojima H, Horio K, Sakaguchi Y, Gotoh K, Satoh T, Hidaka H, Tanaka Y, Hayashi S, Kusano C. Quantification of Streptococcus salivarius using the digital polymerase chain reaction as a liver fibrosis marker. <i>World J Hepatol</i> 2025; 17(4): 102027</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i4/102027.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i4.102027

Full Article (PDF)	WJH-17-102027-with-cover.pdf
Manuscript File	102027_Auto_Edited_012718.docx
Answering Reviewers	102027-answering-reviewers.pdf
Audio Core Tip	102027-audio.mp3
Biostatistics Review Certificate	102027-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102027-conflict-of-interest-statement.pdf
Copyright License Agreement	102027-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102027-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	102027-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	102027-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	102027-non-native-speakers.pdf
Supplementary Material	102027-supplementary-material.pdf
Peer-review Report	102027-peer-reviews.pdf
Scientific Misconduct Check	102027-scientific-misconduct-check.png
Scientific Editor Work List	102027-scientific-editor-work-list.pdf
CrossCheck Report	102027-crosscheck-report.pdf