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Articles Published Processes
3/21/2025 6:10:16 AM | Browse: 17 | Download: 56
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Received |
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2024-10-07 15:38 |
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Peer-Review Started |
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2024-10-07 15:38 |
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To Make the First Decision |
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Return for Revision |
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2025-01-09 02:40 |
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Revised |
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2025-01-17 20:45 |
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Second Decision |
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2025-02-19 02:31 |
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Accepted by Journal Editor-in-Chief |
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2025-02-21 11:52 |
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Accepted by Executive Editor-in-Chief |
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2025-02-24 08:15 |
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Articles in Press |
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2025-02-24 08:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-02-28 02:06 |
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Typeset the Manuscript |
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2025-03-07 06:31 |
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Publish the Manuscript Online |
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2025-03-21 06:10 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Clinical experience with cryopreserved mesenchymal stem cells for cardiovascular applications: A systematic review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Moaz Safwan, Mariam Safwan Bourgleh and Khawaja Husnain Haider |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, AlQaseem, Saudi Arabia. kh.haider@sr.edu.sa |
| Key Words |
Cardiovascular; Cryopreservation; Heart; Mesenchymal stem cells; Umbilical cord stem cells; Randomized control trials; Stem cells |
| Core Tip |
Our study yields significant findings that are crucial for regenerative medicine and cardiology. Our findings revealed that cryopreserved mesenchymal stem cells (CryoMSCs) treatment, compared to the control group, resulted in a 2.11% improvement in left ventricular ejection fraction during six months of follow-up, offering hope for potential future therapies. Left ventricular ejection fraction improvement was higher when using umbilical cord-derived mesenchymal stem cells or CryoMSCs with more than 80% post-thaw viability. The CryoMSCs treatment was safe, as there was no significant difference in the incidence of major cardiac adverse events compared to the control group. Also, no significant effects on mortality and readmission were observed in the CryoMSCs group compared to the control group. |
| Publish Date |
2025-03-21 06:10 |
| Citation |
<p>Safwan M, Bourgleh MS, Haider KH. Clinical experience with cryopreserved mesenchymal stem cells for cardiovascular applications: A systematic review. <i>World J Stem Cells</i> 2025; 17(3): 102067</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i3/102067.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i3.102067 |
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