Publication Name	World Journal of Gastroenterology
Manuscript ID	102070
Country	China

Received	2024-10-08 08:07
Peer-Review Started	2024-10-08 08:07
To Make the First Decision
Return for Revision	2024-11-23 01:39
Revised	2024-12-06 18:26
Second Decision	2024-12-19 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-19 03:12
Articles in Press	2024-12-19 03:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-02 00:29
Publish the Manuscript Online	2025-01-10 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Keratin 1 modulates intestinal barrier and immune response via kallikrein kinin system in ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang-Qian Dong, Ying-Hui Zhang, Juan Luo, Mao-Juan Li, Lan-Qing Ma, Ya-Ting Qi and Ying-Lei Miao
ORCID	Author(s) ORCID Number Juan Luo http://orcid.org/0000-0001-8400-2246 Mao-Juan Li http://orcid.org/0000-0001-9578-7106 Ying-Lei Miao http://orcid.org/0000-0001-8193-5198
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82160113 “Xingdian Talents” Support Project of Yunnan Province No. RLMY20220007 Applied Basic Research Projects of Yunnan Province No. 2019FE001-039 Yunnan Province Clinical Research Center for Digestive Diseases No. 202102AA100062
Corresponding Author	Ying-Lei Miao, Chief Physician, MD, Professor, Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Province Clinical Research Center for Digestive Diseases, No. 295 Xichang Road, Wuhua District, Kunming 650032, Yunnan Province, China. miaoyinglei@yeah.net
Key Words	Keratin 1; Ulcerative colitis; Kallikrein kinin system; Digestive system diseases; Bradykinin; High molecular weight kininogen; Intestinal barrier function; Inflammatory cytokines
Core Tip	Keratin 1 (KRT1) plays a protective role in ulcerative colitis by modulating the kallikrein kinin system and reducing inflammation. KRT1 enhances intestinal barrier function, inhibits inflammatory cytokines, and preserves colon integrity, positioning it as a potential therapeutic target for ulcerative colitis.
Publish Date	2025-01-10 08:40
Citation	<p>Dong XQ, Zhang YH, Luo J, Li MJ, Ma LQ, Qi YT, Miao YL. Keratin 1 modulates intestinal barrier and immune response via kallikrein kinin system in ulcerative colitis. <i>World J Gastroenterol</i> 2025; 31(6): 102070</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i6/102070.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i6.102070

Full Article (PDF)	WJG-31-102070-with-cover.pdf
The ARRIVE Guidelines	102070-The-ARRIVE-Guidelines.pdf
Manuscript File	102070_Auto_Edited-YJP-v3.docx
Answering Reviewers	102070-answering-reviewers.pdf
Audio Core Tip	102070-audio.m4a
Biostatistics Review Certificate	102070-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102070-conflict-of-interest-statement.pdf
Copyright License Agreement	102070-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102070-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	102070-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	102070-non-native-speakers.pdf
Peer-review Report	102070-peer-reviews.pdf
Scientific Misconduct Check	102070-scientific-misconduct-check.png
Scientific Editor Work List	102070-scientific-editor-work-list.pdf
CrossCheck Report	102070-crosscheck-report.png
CrossCheck Report	102070-crosscheck-report.pdf