Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	102083
Country	China

Received	2024-10-08 07:42
Peer-Review Started	2024-10-08 07:42
To Make the First Decision
Return for Revision	2024-12-05 09:41
Revised	2024-12-16 12:10
Second Decision	2025-01-08 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-08 07:30
Articles in Press	2025-01-08 07:30
Publication Fee Transferred	2024-12-19 08:42
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-22 04:17
Publish the Manuscript Online	2025-02-14 10:33

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation
Manuscript Source	Unsolicited Manuscript
All Author List	Jin Zhou, Jing-Rui Chen, Jin-Ming Li, Shuang-Qing Han, Xi-Yue Deng, Zhong-Min Li, Wen Tong, Chao Wang, Yi Bai and Ya-Min Zhang
ORCID	Author(s) ORCID Number Jin Zhou http://orcid.org/0009-0000-8611-927X Jing-Rui Chen http://orcid.org/0009-0002-3930-6712 Wen Tong http://orcid.org/0000-0002-2067-8121 Ya-Min Zhang http://orcid.org/0009-0006-3419-0932
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82372194
Corresponding Author	Ya-Min Zhang, Chief Physician, PhD, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300070, China. zhangyamin@nankai.edu.cn
Key Words	Cholangiocarcinoma; IL-22; IL-22R1; ERK1/2; Cancer progression
Core Tip	This research results show that IL-22R1 is highly expressed in cholangiocarcinoma (CCA) cell lines and tissues. The binding of IL-22 to IL-22R1 forms the IL-22/IL-22R1 axis, which can promote the progression of CCA both in vivo and in vitro. The application of ERK1/2 inhibitors can reverse the promoting effect of IL-22 on CCA, providing potential therapeutic strategies for CCA’s clinical treatment.
Publish Date	2025-02-14 10:33
Citation	<p>Zhou J, Chen JR, Li JM, Han SQ, Deng XY, Li ZM, Tong W, Wang C, Bai Y, Zhang YM. IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation. <i>World J Gastrointest Oncol</i> 2025; 17(3): 102083</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i3/102083.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i3.102083

Full Article (PDF)	WJGO-17-102083-with-cover.pdf
The ARRIVE Guidelines	102083-The-ARRIVE-Guidelines.pdf
Manuscript File	102083_Auto_Edited_010918.docx
Answering Reviewers	102083-answering-reviewers.pdf
Audio Core Tip	102083-audio.mp3
Biostatistics Review Certificate	102083-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102083-conflict-of-interest-statement.pdf
Copyright License Agreement	102083-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102083-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	102083-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	102083-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	102083-non-native-speakers.pdf
Supplementary Material	102083-supplementary-material.pdf
Peer-review Report	102083-peer-reviews.pdf
Scientific Misconduct Check	102083-scientific-misconduct-check.png
Scientific Editor Work List	102083-scientific-editor-work-list.pdf
CrossCheck Report	102083-crosscheck-report.pdf
CrossCheck Report	102083-crosscheck-report.png