Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	102084
Country	China

Received	2024-10-10 02:51
Peer-Review Started	2024-10-10 02:51
To Make the First Decision
Return for Revision	2025-01-17 13:16
Revised	2025-01-27 04:29
Second Decision	2025-02-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-14 06:11
Articles in Press	2025-02-14 06:11
Publication Fee Transferred	2025-01-31 02:22
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-04 15:21
Publish the Manuscript Online	2025-03-25 16:18

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	MEX3A promotes cell proliferation by regulating the RORA/β-catenin pathway in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Peng-Xiang Ji, Ping Zhang, Hui-Ling Zhou, Hong Yu and Yi Fu
ORCID	Author(s) ORCID Number Peng-Xiang Ji http://orcid.org/0000-0001-9455-1564 Yi Fu http://orcid.org/0000-0002-3820-8996
Funding Agency and Grant Number	Funding Agency Grant Number Suzhou Municipal Science and Technology Bureau SYS2020081
Corresponding Author	Yi Fu, Associate Professor, PhD, Department of Human Anatomy, Histology and Embryology, Suzhou Medical College of Soochow University, No. 199 Renai Road, Suzhou 215123, Jiangsu Province, China. yfu@suda.edu.cn
Key Words	Hepatocellular carcinoma; MEX3A; Proliferation; Migration; Wnt/β-catenin; Epithelial-mesenchymal transition pathway; RORA
Core Tip	This study found that MEX3A was highly expressed in hepatocellular carcinoma (HCC) and associated with poor prognosis. Immunohistochemistry showed that MEX3A expression was positively correlated with Ki-67 and vimentin, and closely related to clinical parameters. Knockdown of MEX3A inhibited cell proliferation and cell cycle progression; attenuated expression of β-catenin, c-Myc and cyclin D1; inhibited nuclear entry of β-catenin; and downregulated epithelial-mesenchymal transition to inhibit cell migration. Transcription factor analysis found that RORA might mediate the effects of MEX3A. In conclusion, MEX3A may promote proliferation of HCC cells by regulating the RORA/β-catenin pathway.
Publish Date	2025-03-25 16:18
Citation	<p>Ji PX, Zhang P, Zhou HL, Yu H, Fu Y. MEX3A promotes cell proliferation by regulating the RORA/β-catenin pathway in hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2025; 17(4): 102084</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i4/102084.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i4.102084

Full Article (PDF)	WJGO-17-102084-with-cover.pdf
Manuscript File	102084_Auto_Edited_012421.docx
Answering Reviewers	102084-answering-reviewers.pdf
Audio Core Tip	102084-audio.wav
Biostatistics Review Certificate	102084-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102084-conflict-of-interest-statement.pdf
Copyright License Agreement	102084-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102084-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	102084-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	102084-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	102084-non-native-speakers.pdf
Supplementary Material	102084-supplementary-material.pdf
Peer-review Report	102084-peer-reviews.pdf
Scientific Misconduct Check	102084-scientific-misconduct-check.png
Scientific Editor Work List	102084-scientific-editor-work-list.pdf
CrossCheck Report	102084-crosscheck-report.pdf